FlyBase Gene Summary FBgn0003733 tor torso Drosophila melanogaster CG1389 CG1389 splc: spliced Tor splc spliced 20 Aug 04 2R complement(2766074..2770092) AE003840 tor-RA tor-PA (923 aa) transmembrane receptor protein tyrosine kinase activity ; ; EC:2.7.1.- inferred from sequence similarity protein-tyrosine kinase activity ; ; EC:2.7.1.112 non-traceable author statement protein-tyrosine kinase activity ; ; EC:2.7.1.112 transmembrane receptor protein tyrosine kinase activity ; ; EC:2.7.1.- Malpighian tubule morphogenesis cell fate determination determination of anterior/posterior axis, embryo ectoderm development eggshell pattern formation (sensu Insecta) neurogenesis protein amino acid phosphorylation terminal region determination torso signaling pathway plasma membrane embryo nurse cell oogenesis, adult oocyte germarium IPR000719 == Eukaryotic protein kinase IPR001245 == Tyrosine kinase catalytic domain SCOP:56112 == Protein kinase-like (PK-like); tor|FBgn0003733|pp-CT3198|FBan0001389 DEDB:13278 FlyGRID:FBgn0003733 IFly:../torstoll/torso1.htm NCBI_GEO:FBgn0003733 FBrf0157176 Furriols and Casanova 2003 EMBO J. 22(9): 1947--1952 Review FBrf0141280 Johnstone and Lasko 2001 A. Rev. Genet. 35: 365--406 Review FBrf0159910 Casci 2000 Nature Rev. Genet. 1(1): 9 Review

The D. melanogaster gene torso, abbreviated as tor, is reported here. It encodes a product with protein-tyrosine kinase activity (EC:2.7.1.112) involved in protein amino acid phosphorylation which is localized to the plasma membrane; it is expressed in the ovary (germarium, nurse cell and oocyte). It has been sequenced and its amino acid sequence contains an eukaryotic protein kinase and a tyrosine kinase catalytic domain. It has been mapped by recombination to 2-57 and cytologically to 43E12. It interacts genetically with Ras85D, rl, Dsor1, dpp, Sos and 62 other listed genes. There are 127 recorded alleles: 35 in vitro constructs (none available from the public stock centers), 91 classical mutants (3 available from the public stock centers) and 1 wild-type. Amorphic mutations have been isolated which affect the maternal effect embryonic/first instar larval cuticle, the embryonic maternal effect labral segment, the maternal effect telson and 17 other listed tissues and are embryonic recessive maternal effect lethal and recessive female sterile. tor is discussed in 361 references (excluding sequence accessions), dated between 1986 and 2004. These include at least 55 studies of mutant phenotypes, 2 studies of wild-type function and 8 molecular studies. Among findings on tor mutants, mutation in tor results in a maternal effect phenotype with defects during the early stages of gastrulation and defects in the anteroposterior axis.

FlyBase Gene Summary FBgn0000015 Abd-B Abdominal B Drosophila melanogaster CG11648 CG10291 tuh-3 Mcp: Miscadastral pigmentation iab-5 iab-8 iab-7 AbdB twig Sab: Superabdominal Tab: Transabdominal iab5: infra-abdominal 5 iab6: infra-abdominal 6 iab7: infra-abdominal 7 iab8: infra-abdominal 8 iab9: infra-abdominal 9 Mc: Microcephalus FAB MCP Fab7 DROABDB Fab-7 Abd B abdB AbdB(CA)<down>26</down> ABDB pH189 abd-B AbdB-I AbdB-II iab-6 Abd-b Abdominal-B Uab-5<up>Sab</up> iab8.9: infraabdominal-8.9 iab: infraabdominal l(3)89Ed Mcp iab6 iab7 iab8 iab9 iab5 infraabdominal-8.9 Miscadastral pigmentation Male chauvinist pigmentation Microcephalus Transabdominal Mc Superabdominal Sab infraabdominal Tab infra-abdominal 5 infra-abdominal 6 infra-abdominal 7 infra-abdominal 8 infra-abdominal 9 21 Aug 04 3R complement(12752947..12797973) AE003715 Abd-B-RE Abd-B-PE (270 aa) Abd-B-RB Abd-B-PB (493 aa) Abd-B-RD Abd-B-PD (270 aa) Abd-B-RA Abd-B-PA (270 aa) Abd-B-RC Abd-B-PC (270 aa) specific RNA polymerase II transcription factor activity non-traceable author statement specific RNA polymerase II transcription factor activity determination of anterior/posterior axis, embryo genital disc development genital morphogenesis (sensu Holometabola) germ cell migration gonad development heart development midgut development negative regulation of cardioblast cell fate specification negative regulation of myogenesis negative regulation of salivary gland determination pigmentation positive regulation of pigmentation regulation of transcription from Pol II promoter salivary gland development sex differentiation sex-specific pigmentation specification of segmental identity, abdomen nucleus embryo parasegment 13 parasegment 11..13 <of> embryonic central nervous system parasegment 10..14 parasegment 14 parasegment 14 <of> embryonic central nervous system IPR001356 == Homeobox domain SCOP:46689 == Homeodomain-like; Abd-B|FBgn0000015|pp-CT28893|FBan0010291 SCOP:46689 == Homeodomain-like; Abd-B|FBgn0000015|pp-CT40560|FBan0010291 DEDB:9547 FlyGRID:FBgn0000015 IFly:../segment/abdomlb1.htm KWgx:FBgn0000015 NCBI_GEO:FBgn0000015 FBrf0159337 Abrams et al. 2003 Trends Cell Biol. 13(5): 247--254 Review FBrf0152334 Burtis 2002 Science 297(5584): 1135--1136 Review FBrf0156093 Christiansen et al. 2002 Trends Genet. 18(10): 510--516 Review FBrf0151731 Duncan 2002 A. Rev. Genet. 36: 521--556 Review FBrf0155986 Simpson 2002 Nature Rev. Genet. 3(12): 907--917 Review

The D. melanogaster gene Abdominal B, abbreviated as Abd-B, is reported here. It has also been known in FlyBase as CG10291, CG11648, MS:AbdB.CA26, MS:DROABDB and Mc. It encodes a product with specific RNA polymerase II transcription factor activity involved in pigmentation which is localized to the nucleus; it is expressed in the embryo (Malpighian tubule, ectoderm, epidermis, parasegment 10 and 15 other listed tissues) and larva (female genital disc and male genital disc). It has been sequenced and its amino acid sequence contains a homeobox domain. It has been mapped by recombination to 3-58.8 and cytologically to 89E4--5. It interacts genetically with Pcl, tuh1, Ubx, Scm, ph-d and 15 other listed genes. There are 186 recorded alleles: 15 in vitro constructs (none available from the public stock centers), 170 classical mutants (12 available from the public stock centers) and 1 wild-type. Amorphic mutations have been isolated which affect the somatic clone abdominal segment 5 to 8, the embryonic somatic clone abdominal segment 8, the somatic clone sclerite and 9 other listed tissues and are dominant male sterile, dominant female sterile, recessive lethal, homeotic somatic clone visible, somatic clone (with Df(3R)P9) body color defective and (with Df(3R)P9) lethal. Abd-B is discussed in 497 references (excluding sequence accessions), dated between 1944 and 2004. These include at least 24 studies of mutant phenotypes, 18 studies of wild-type function, 4 studies of natural polymorphisms and 49 molecular studies. Among findings on Abd-B mutants, recessive Mcp group mutations of Abd-B have been isolated as revertants and partial revertants of dominant gain-of-function Abd-B alleles. Among findings on Abd-B function, Abd-B divides the primordium of the posterior spiracle into two cell populations that develop using distinct morphogenetic mechanisms into the spiracular chamber and the stigmatophore. (However, there is much more information on function so that may not be representative.)

FlyBase Gene Summary FBgn0003495 spz spatzle Drosophila melanogaster CG6134 CG6134 CG6134 spaetzle mel(3)7 20 Aug 04 3R complement(22880157..22885155) AE003759 spz-RJ spz-PJ (244 aa) spz-RI spz-PI (227 aa) spz-RH spz-PH (249 aa) spz-RG spz-PG (223 aa) spz-RF spz-PF (174 aa) spz-RE spz-PE (181 aa) spz-RD spz-PD (273 aa) spz-RC spz-PC (253 aa) spz-RB spz-PB (300 aa) spz-RA spz-PA (326 aa) Toll binding inferred from genetic interaction with FLYBASE:Tl; FB:FBgn0003717 Toll binding non-traceable author statement Toll binding traceable author statement morphogen activity non-traceable author statement cytokine activity traceable author statement morphogen activity cytokine activity Toll binding Toll signaling pathway antifungal humoral response (sensu Protostomia) antifungal polypeptide induction defense response dorsal/ventral axis specification embryonic axis specification immune response innate immune response maternal determination of dorsal/ventral axis, oocyte, germ-line encoded oocyte dorsal/ventral axis determination response to fungi extracellular oogenesis, adult ovary BDGPisx:spz DEDB:10835 FlyGRID:FBgn0003495 IFly:../torstoll/spatzle.htm NCBI_GEO:FBgn0003495 FBrf0149180 Khush et al. 2002 Science 296: 273--275 Review FBrf0148941 Stathopoulos and Levine 2002 Dev. Biol. 246(1): 57--67 Review FBrf0156068 Imler and Hoffmann 2001 Trends Cell Biol. 11(7): 304--311 Review FBrf0141281 Lall and Patel 2001 A. Rev. Genet. 35: 407--437 Review FBrf0139665 Silverman and Maniatis 2001 Genes Dev. 15(18): 2321--2342 Review

The D. melanogaster gene spatzle, abbreviated as spz, is reported here. It encodes a product with Toll binding involved in maternal determination of dorsal/ventral axis, oocyte, germ-line encoded which is localized to the extracellular matrix; it is expressed in the ovary (ovary). It has been sequenced and its amino acid sequence is also available. It has been mapped by recombination to 3-92 and cytologically to 97E1. It interacts genetically with cact, tld, yeti, nec and cic. There are 49 recorded alleles: 22 in vitro constructs (none available from the public stock centers), 26 classical mutants (3 available from the public stock centers) and 1 wild-type. Amorphic mutations have been isolated which affect the embryonic ventral maternal effect cuticle, the embryonic/larval somatic muscle, the supernumerary (with spz1.9/Df(3R)Bd) ventral furrow and the (with spzbcd.3'UTR/Df(3R)Bd) embryonic/first instar larval cuticle and are embryonic maternal effect recessive lethal and conditional immune response defective. spz is discussed in 182 references (excluding sequence accessions), dated between 1984 and 2004. These include at least 7 studies of mutant phenotypes, 2 studies of wild-type function and 8 molecular studies. Among findings on spz function, spz is required for muscle development in the embryo.

FlyBase Gene Summary FBgn0003391 shg shotgun Drosophila melanogaster CG3722 cadherin gp150 D-cad DE-cadherin E-cadherin DE-Cadherin Drosophila E-Cadherin DE-cad E-Cadherin DECad CADH l(2)k03401 l(2)k10220 Cad D-Ecadherin DE-CAD Cadherin DEC DCad DCAD2 Ecad DE<up>cyto</up> DE CT12481 shg/DE-Cad Shg DE-Cad E-cad De-cadherin E-Cad CadE l(2)10469 shg Cadherin-E Drosophila E-cadherin 20 Aug 04 2R complement(16094146..16100703) AE003452 shg-RA shg-PA (1507 aa) beta-catenin binding non-traceable author statement receptor activity inferred from sequence similarity cell adhesion molecule binding inferred from sequence similarity receptor activity cell adhesion molecule binding beta-catenin binding asymmetric cytokinesis axon guidance border cell migration (sensu Insecta) calcium-dependent cell-cell adhesion cell projection biogenesis establishment and/or maintenance of cell polarity female germ-line cyst encapsulation (sensu Insecta) follicle cell migration (sensu Insecta) gastrulation (sensu Insecta) germ cell migration germ-line stem cell renewal gonad development gonadal mesoderm development head involution heart development homophilic cell adhesion morphogenesis of an epithelium neurogenesis oocyte anterior/posterior axis determination oocyte positioning oogenesis (sensu Insecta) optic placode development (sensu Drosophila) pole cell migration signal transduction somatic stem cell maintenance somatic stem cell renewal tracheal branch fusion tracheal system development (sensu Insecta) adherens junction cell-cell adherens junction integral to membrane integral to plasma membrane plasma membrane spot adherens junction zonula adherens embryo gonadal sheath dorsal ectoderm ventral neurectoderm embryonic/larval tracheal system midgut primordium oogenesis embryonic/larval dorsal vessel IPR000233 == Cadherin cytoplasmic region IPR002126 == Cadherin domain SCOP:49313 == Cadherin; shg|FBgn0003391|pp-CT12481|FBan0003722 SCOP:49899 == Concanavalin A-like lectins/glucanases; shg|FBgn0003391|pp-CT12481|FBan0003722 BDGPisx:shg DEDB:1101 FlyGRID:FBgn0003391 IFly:../gene/shotgun.htm KWgx:FBgn0003391 NCBI_GEO:FBgn0003391 FBrf0159315 Cereijido et al. 2003 Prog. Biophys. Molec. Biol. 81(2): 81--115 Review FBrf0155680 Muller 2003 Dev. Cell 4(1): 1--3 Review FBrf0157202 Perez-Moreno 2003 Cell 112(4): 535--548 Review

The D. melanogaster gene shotgun, abbreviated as shg, is reported here. It has also been known in FlyBase as CadE and l(2)10469. It encodes a product with beta-catenin binding involved in heart development which is a component of the plasma membrane; it is expressed in the embryo (Malpighian tubule, amnioserosa, dorsal ectoderm, embryonic epidermis and 11 other listed tissues). It has been sequenced. It has been mapped by recombination to 2-92 and cytologically to 57B15--16. It interacts genetically with arm, AGO1, zep, N, ct and 28 other listed genes. There are 57 recorded alleles: 39 in vitro constructs (none available from the public stock centers), 17 classical mutants (2 available from the public stock centers) and 1 wild-type. Amorphic mutations have been isolated which affect the endoderm, the ventral embryonic epidermis, the germ-line clone ovary and 20 other listed tissues and are embryonic recessive lethal and cell death increase. shg is discussed in 318 references (excluding sequence accessions), dated between 1984 and 2004. These include at least 26 studies of mutant phenotypes, 8 studies of wild-type function and 10 molecular studies. Among findings on shg mutants, phenotypic analysis of mutants suggests that shg functions to direct adhesion between midgut epithelial cells, and that this adhesion is independent of the adhesion between endoderm and visceral mesoderm. Among findings on shg function, shg regulates several aspects of tracheal tube fusion. (However, there is much more information on function so that may not be representative.)

FlyBase Gene Summary FBgn0002576 lz lozenge Drosophila melanogaster CG1689 fs(1)M69 amx Lz fs(1)A1569 spe: spectacled spectacled 20 Aug 04 X 9023633..9042621 AE003446 lz-RA lz-PA (826 aa) transcription factor activity non-traceable author statement RNA polymerase II transcription factor activity inferred from genetic interaction with FLYBASE:B; FB:FBgn0000154 RNA polymerase II transcription factor activity inferred from genetic interaction with FLYBASE:svp; FB:FBgn0003651 RNA polymerase II transcription factor activity inferred from sequence similarity with FLYBASE:run; FB:FBgn0003300 RNA polymerase II transcription factor activity inferred from sequence similarity with HUGO:RUNX1; OMIM:151385 RNA polymerase II transcription factor activity, enhancer binding non-traceable author statement RNA polymerase II transcription factor activity transcription factor activity RNA polymerase II transcription factor activity, enhancer binding antennal morphogenesis cell differentiation cell fate commitment cell fate determination crystal cell differentiation defense response embryonic crystal cell differentiation embryonic hemopoiesis eye morphogenesis (sensu Drosophila) hemopoiesis lymph gland crystal cell differentiation lymph gland hemocyte differentiation (sensu Arthropoda) negative regulation of transcription from Pol II promoter oogenesis (sensu Insecta) positive regulation of transcription from Pol II promoter signal transduction spermathecum morphogenesis nucleus IPR000040 == Acute myeloid leukemia 1 protein (AML 1)/Runt SCOP:49417 == p53-like transcription factors; lz|FBgn0002576|pp-CT4670|FBan0001689 DEDB:948 FlyGRID:FBgn0002576 IFly:../newgene/lozenge.htm NCBI_GEO:FBgn0002576 FBrf0144845 Fossett and Schulz 2001 Differentiation 69(2-3): 83--90 Review FBrf0127022 Brennan and Moses 2000 Cell. Molec. Life Sci. 57(2): 195--214 Review FBrf0103259 Fisher and Caudy 1998 Genes Dev. 12(13): 1931--1940 Review FBrf0102455 Parkhurst 1998 Trends Genet. 14(4): 130--132 Review

The D. melanogaster gene lozenge, abbreviated as lz, is reported here. It encodes a product with RNA polymerase II transcription factor activity involved in embryonic hemopoiesis which is a component of the nucleus. It has been sequenced. It has been mapped by recombination to 1-27.7 and cytologically to 8D12. It interacts genetically with su(f), Bgb, sv, Bc, e(we) and 19 other listed genes. There are 154 recorded alleles: 15 in vitro constructs (none available from the public stock centers), 138 classical mutants (20 available from the public stock centers) and 1 wild-type. Amorphic mutations have been isolated which affect the antennal segment 3, the sensillum basiconicum of antennal segment 3, the sensillum trichodeum of antennal segment 3 and 10 other listed tissues and are recessive visible and cell death increase. lz is discussed in 246 references (excluding sequence accessions), dated between 1925 and 2004. These include at least 23 studies of mutant phenotypes, 8 studies of wild-type function and 6 molecular studies. Among findings on lz mutants, mating studies of lz mutants suggests that antennal basiconic sensilla are important for neither the perception of the attraction pheromones of virgin females nor the inhibitory pheromone of mated females. Among findings on lz function, lz acts in a dose-dependent manner to specify the fate of the sensilla trichoidea and sensilla basiconica in the antenna.

FlyBase Gene Summary FBgn0004636 R Roughened Drosophila melanogaster CG1956 Dras3 l(3)R Rap1 l(3)62Bf E(faf) Dras62B RAP1 ras3 RasIII rap1 ras 3 DRap DRap1 Rap C-ras3 Ras3 BEST:GH18528 Enhancer of faf 20 Aug 04 3L complement(1839743..1842863) AE003473 R-RA R-PA (184 aa) GTP binding GTP binding non-traceable author statement GDP binding non-traceable author statement GTPase activity GDP binding GTPase activity inferred from sequence similarity with SGD_LOCUS:RAS1; SGD:S0005627 G-protein coupled receptor protein signaling pathway NOT regulation of JNK cascade cell adhesion cytokinesis dorsal closure intracellular protein transport mitosis photoreceptor fate commitment (sensu Drosophila) receptor mediated endocytosis regulation of cell shape regulation of exocytosis stalk formation adult genital disc embryo dorsal mesothoracic disc larva eye-antennal disc oogenesis, adult oocyte IPR001806 == Ras GTPase superfamily IPR003577 == RAS small GTPases, Ras subfamily SCOP:52540 == P-loop containing nucleotide triphosphate hydrolases; R|FBgn0004636|pp-CT6117|FBan0001956 DEDB:2046 FlyGRID:FBgn0004636 Hybrigenics:522180 NCBI_GEO:FBgn0004636 FBrf0128450 Dobens and Raftery 2000 Dev. Dynamics 218(1): 80--93 Review

The D. melanogaster gene Roughened, abbreviated as R, is reported here. It has also been known in FlyBase as BEST:GH18528. It encodes a product with GDP binding involved in dorsal closure which is expressed in the adult (abdominal ganglion, adult brain and thoracic ganglion), larva (dorsal mesothoracic disc, embryonic/larval brain, eye-antennal disc and genital disc) and ovary (oocyte). It has been sequenced and its amino acid sequence contains a ras GTPase superfamily and a RAS small GTPases, Ras subfamily. It has been mapped by recombination to 3-1.4 and cytologically to 62B7. It interacts genetically with faf, dap, Rapgap1, C3G and cno. There are 37 recorded alleles: 10 in vitro constructs (none available from the public stock centers), 26 classical mutants (1 available from the public stock centers) and 1 wild-type. Loss-of-function mutations have been isolated which affect the eye, the ovary, the egg chamber and 6 other listed tissues and are wild-type and larval lethal. R is discussed in 70 references (excluding sequence accessions), dated between 1951 and 2004. These include at least 12 studies of mutant phenotypes, 2 studies of wild-type function, one study of natural polymorphisms and 8 molecular studies. Among findings on R mutants, R mutations disrupt the normal cell fate specification in photoreceptor cells. Among findings on R function, Ras85D and R seem to function via distinct pathways.

FlyBase Gene Summary FBgn0003691 th thread Drosophila melanogaster CG12284 DIAP1 l(3)j5C8 D-IAP1 diap1 dIAP-1 D-iap1 Diap1 dIAP1 DIAP-1 IAP DIAP dIAP diap-1 Diap-1/Th Diap-1 diap1/thread E(rpr)3-1 Iap1: Inhibitor of apoptosis 1 l(3)72Dc Inhibitor of apoptosis 1 20 Aug 04 3L complement(15987284..15999534) AE003528 th-RA th-PA (438 aa) th-RC th-PC (438 aa) th-RB th-PB (438 aa) ubiquitin-protein ligase activity ; ; EC:6.3.2.19 traceable author statement ubiquitin-protein ligase activity ; ; EC:6.3.2.19 anti-apoptosis apoptosis cell growth and/or maintenance development germ cell migration inhibition of caspase activation negative regulation of apoptosis protein monoubiquitination protein ubiquitination during ubiquitin-dependent protein catabolism spermatid nuclear differentiation embryo eye-antennal disc SCOP:57924 == Inhibitor of apoptosis (IAP) repeat; th|FBgn0003691|pp-CT18339|FBan0012284 SCOP:57924 == Inhibitor of apoptosis (IAP) repeat; th|FBgn0003691|pp-CT43237|FBan0012284 BDGPisx:th DEDB:3930 FlyGRID:FBgn0003691 Hybrigenics:521236 Hybrigenics:521527 KWgx:FBgn0003691 NCBI_GEO:FBgn0003691 FBrf0158735 Claveria and Torres 2003 Biochem. biophys. Res. Commun. 304(3): 531--537 Review FBrf0156082 Ditzel and Meier 2002 Trends Cell Biol. 12(10): 449--452 Review FBrf0147184 Gorski and Marra 2002 Physiol. Genomics 9(2): 59--69 Review FBrf0151230 Martin 2002 Cell 109(7): 793--796 Review FBrf0152250 Palaga and Osborne 2002 Nature Cell Biol. 4(6): E149--E151 Review FBrf0149068 Richardson and Kumar 2002 J. Immunol. Methods 265(1-2): 21--38 Review

The D. melanogaster gene thread, abbreviated as th, is reported here. It has also been known in FlyBase as Iap1. It encodes a product with ubiquitin-protein ligase activity (EC:6.3.2.19) involved in anti-apoptosis which is expressed in the larva (eye-antennal disc). It has been sequenced. It has been mapped by recombination to 3-43.2 and cytologically to 72D1. It interacts genetically with rpr, W, Nc, Ark, grim and 12 other listed genes. There are 78 recorded alleles: 41 in vitro constructs (1 available from the public stock centers), 36 classical mutants (4 available from the public stock centers) and 1 wild-type. Loss-of-function mutations have been isolated which affect the embryo and are recessive lethal. th is discussed in 206 references (excluding sequence accessions), dated between 1957 and 2004. These include at least 31 studies of mutant phenotypes, 5 studies of wild-type function and 9 molecular studies. Among findings on th mutants, th mutants exhibit cellularization defects. Among findings on th function, th is necessary to block apoptosis very early in embryonic development.

FlyBase Gene Summary FBgn0003731 Egfr Epidermal growth factor receptor Drosophila melanogaster CG10079 CG10079 CG10079 CG10079 c-erbB flb: faint little ball top: torpedo DER torpedo l(2)57DEFa Elp top/flb Ellipse top/DER l(2)05351 Egf-r DER/top EGFr DER/faint little ball EGF-R torpedo/Egfr Ellipse torpedo Torpedo/DER EGFR DER-Ellipse Degfr D-Egf Torpedo/Egfr Der: Drosophila epidermal growth factor receptor homologue DmHD-33 DER flb egfr torpedo/DER Elp-1 Elp-B1 Elp-B1RB1 epidermal growth factor receptor DER/EGFR EGF Receptor EGF receptor EgfR Torpedo DER\torpedo EK2-6 Egf l(2)09261 dEGFR EGF-receptor dEGFR1 D-EGFR C-erb El: Ellipse HD-33 l(2)57EFa l(2)57Ea top flb Egfr Der faint little ball Drosophila epidermal growth factor receptor homologue 20 Aug 04 2R 16566556..16602978 AE003454 Egfr-RA Egfr-PA (1377 aa) Egfr-RB Egfr-PB (1426 aa) transmembrane receptor activity traceable author statement epidermal growth factor receptor activity inferred from sequence similarity epidermal growth factor receptor activity traceable author statement gurken receptor activity non-traceable author statement protein-tyrosine kinase activity ; ; EC:2.7.1.112 non-traceable author statement protein-tyrosine kinase activity ; ; EC:2.7.1.112 transmembrane receptor activity epidermal growth factor receptor activity gurken receptor activity epidermal growth factor receptor activity inferred from sequence similarity with UniProt:P00533 G2/M transition of mitotic cell cycle Malpighian tubule morphogenesis R7 differentiation antennal morphogenesis anterior/posterior pattern formation anti-apoptosis blastoderm segmentation border cell migration (sensu Insecta) brain development branch cell fate determination (sensu Insecta) cell fate commitment cell fate determination cell projection biogenesis compound eye morphogenesis (sensu Drosophila) cone cell fate commitment (sensu Drosophila) dorsal closure dorsal/ventral axis specification dorsal/ventral pattern formation eggshell pattern formation (sensu Insecta) embryonic axis specification embryonic pattern specification epidermal growth factor receptor signaling pathway eye morphogenesis (sensu Drosophila) female germ-line cyst encapsulation gastrulation germ-band shortening gurken receptor signaling pathway imaginal disc development imaginal disc pattern formation leg disc proximal/distal pattern formation male germ-line cyst encapsulation maternal determination of dorsal/ventral axis, follicular epithelium, soma encoded (sensu Insecta) morphogenesis of an epithelium morphogenesis of follicular epithelium muscle attachment muscle cell fate specification negative regulation of retinal programmed cell death (sensu Drosophila) notum morphogenesis oenocyte differentiation ommatidial rotation oocyte anterior/posterior axis determination (sensu Insecta) oocyte anterior/posterior axis determination oocyte dorsal/ventral axis determination oogenesis (sensu Insecta) photoreceptor differentiation (sensu Drosophila) photoreceptor fate commitment (sensu Drosophila) progression of morphogenetic furrow (sensu Drosophila) protein amino acid phosphorylation regulation of R8 spacing regulation of mitotic cell cycle salivary gland development second mitotic wave (sensu Drosophila) stomatogastric nervous system development tracheal system development (sensu Insecta) wing disc metamorphosis wing disc proximal/distal pattern formation wing morphogenesis wing vein morphogenesis wing vein specification integral to plasma membrane plasma membrane adult genital disc imaginal disc larval brain ovary embryo larval brain dorsal mesothoracic disc nurse cell ectoderm stomodeum labral segment embryonic gnathal segment embryonic/larval midgut embryonic/larval proventriculus embryonic/larval fat body embryonic/larval pharynx cephalic furrow ventral midline larva eye-antennal disc oocyte celular blastoderm mesoderm embryonic/larval posterior spiracle antennal disc oogenesis follicle cell pupa imaginal disc pupa, adult embryonic telson IPR000494 == Epidermal growth-factor receptor (EGFR), L domain IPR000719 == Eukaryotic protein kinase IPR001245 == Tyrosine kinase catalytic domain IPR002174 == Furin-like cysteine rich region SCOP:48695 == Multiheme cytochromes; Egfr|FBgn0003731|pp-CT28361|FBan0010079 SCOP:52058 == L domain-like; Egfr|FBgn0003731|pp-CT28361|FBan0010079 SCOP:56112 == Protein kinase-like (PK-like); Egfr|FBgn0003731|pp-CT28361|FBan0010079 SCOP:57184 == IGF binding domain; Egfr|FBgn0003731|pp-CT28361|FBan0010079 BDGPisx:Egfr DEDB:1232 FlyGRID:FBgn0003731 IFly:../torstoll/egf-r1.htm NCBI_GEO:FBgn0003731 FBrf0155681 Affolter et al. 2003 Dev. Cell 4(1): 11--18 Review FBrf0158927 Shilo 2003 Exp. Cell Res. 284(1): 140--149 Review FBrf0158727 de Celis 2003 BioEssays 25(5): 443--451 Review

The D. melanogaster gene Epidermal growth factor receptor, abbreviated as Egfr, is reported here. It has also been known in FlyBase as HD-33 and l(2)05351. It encodes a product with epidermal growth factor receptor activity involved in eye morphogenesis (sensu Drosophila) which is a component of the integral to plasma membrane; it is expressed in the adult (cerebral cortex, follicle cell, proventriculus and thoracic ganglion), embryo (apodeme, cellular blastoderm, celular blastoderm, cephalic furrow and 19 other listed tissues), larva (Malpighian tubule, antennal disc, dorsal mesothoracic disc, embryonic/larval salivary gland and 15 other listed tissues), ovary (follicle cell, nurse cell and oocyte) and prepupa and pupa (adult foregut, adult hindgut and adult fat body). It has been sequenced and its amino acid sequence contains an epidermal growth-factor receptor (EGFR), L domain, an eukaryotic protein kinase, a tyrosine kinase catalytic domain and a furin-like cysteine rich region. It has been mapped by recombination to 2-101 and cytologically to 57E9--F1. It interacts genetically with vn, ed, N, rho, Ras85D and 81 other listed genes. There are 139 recorded alleles: 27 in vitro constructs (2 available from the public stock centers), 111 classical mutants (6 available from the public stock centers) and 1 wild-type. Amorphic mutations have been isolated which affect the somatic clone wing, the somatic clone leg, the somatic clone head and 8 other listed tissues and are embryonic recessive lethal, partially somatic clone cell lethal and recessive visible. Egfr is discussed in 835 references (excluding sequence accessions), dated between 1960 and 2004. These include at least 136 studies of mutant phenotypes, 33 studies of wild-type function and 15 molecular studies. Among findings on Egfr mutants, Egfr is necessary for proper wing venation, development of the arista, legs and female genital disc and mutations alter the distribution of macrochaetae. Among findings on Egfr function, Egfr signalling regulates ommatidial rotation and cell motility in the eye. (However, there is much more information on function so that may not be representative.)

FlyBase Gene Summary FBgn0003028 ovo ovo Drosophila melanogaster CG6824 CG15467 CG6824 CG15467 fs(1)M1 fs(1)M38 Fs(1)K1103 svb: shaven baby Ovo fs(1)K1237 ovo/svb Shavenbaby Svb OVO ovo/shaven-baby shaven baby shavenbaby ovo/shavenbaby Ovo-D Fs(1)K1237 Fs(1)K155 svb 20 Aug 04 X 4788911..4810318 AE003433 ovo-RC ovo-PC (1222 aa) ovo-RB ovo-PB (1351 aa) ovo-RA ovo-PA (975 aa) DNA binding DNA binding traceable author statement RNA polymerase II transcription factor activity inferred from sequence similarity with PIR:S59069 RNA polymerase II transcription factor activity cuticle biosynthesis female germ-line sex determination oogenesis (sensu Insecta) pheromone metabolism regulation of transcription transcription from Pol II promoter nucleus embryo pole cell embryonic labial segment dorsal ridge stomatogastric nervous system dorsal hair embryonic/larval pharynx antenna intercalary segment denticle belt gonad cephalic furrow oogenesis nurse cell egg chamber oogenesis, adult follicle cell nurse cell germarium IPR000822 == Zinc finger, C2H2 type SCOP:57667 == C2H2 and C2HC zinc fingers; ovo|FBgn0003028|pp-CT21113|FBan0006824 SCOP:57667 == C2H2 and C2HC zinc fingers; ovo|FBgn0003028|pp-CT36311|FBan0006824 DEDB:523 FlyGRID:FBgn0003028 IFly:../dbzhnsky/ovo1.htm NCBI_GEO:FBgn0003028 FBrf0132358 Mahowald 2001 Etkin, Jeon, 2001: 187--213 Review FBrf0125416 Schutt and Nothiger 2000 Development 127(4): 667--677 Review FBrf0102689 Perrimon 1998 Int. J. Dev. Biol. 42(3): 243--247 Review

The D. melanogaster gene ovo is reported here. It has also been known in FlyBase as CG15467. It encodes a product with RNA polymerase II transcription factor activity involved in regulation of transcription which is localized to the nucleus; it is expressed in the adult (male germline stem cell), embryo (antenna, cephalic furrow, denticle belt, dorsal hair and 8 other listed tissues), larva (gonad) and ovary (female germline stem cell, follicle cell, germarium, nurse cell and 2 other listed tissues). It has been sequenced and its amino acid sequence contains a zinc finger, C2H2 type. It has been mapped by recombination to 1-10.2 and cytologically to 4E2. It interacts genetically with mle, snf, Sxl, Egfr, Ras85D and 6 other listed genes. There are 172 recorded alleles: 41 in vitro constructs (1 available from the public stock centers), 130 classical mutants (7 available from the public stock centers) and 1 wild-type. Amorphic mutations have been isolated which affect the egg chamber and are polyphasic lethal. ovo is discussed in 203 references (excluding sequence accessions), dated between 1977 and 2065. These include at least 26 studies of mutant phenotypes, 7 studies of wild-type function, one study of natural polymorphisms and 8 molecular studies. Among findings on ovo mutants, ovo mutants display short denticles that are reduced in number and an absence of dorsal hairs. Among findings on ovo function, ovo is necessary and sufficient for cells to grow F-actin based extensions.

FlyBase Gene Summary FBgn0000014 abd-A abdominal A Drosophila melanogaster CG10325 CG10325 Hab: Hyperabdominal iab-2 iab-5 abdA AbdA abd-a iab-4 Cbxd: Contrabithoraxoid iab2: infra-abdominal 2 iab3: infra-abdominal 3 iab4: infra-abdominal 4 abd A Abd-A abda DmabdA iab-3 Abda Ultraabdominal iab: infraabdominal l(3)89Ec iab4 Hab Cbxd Contrabithoraxoid infra-abdominal 2 infraabdominal infra-abdominal 3 infra-abdominal 4 iab2 iab3 Hyperabdominal 20 Aug 04 3R complement(12633362..12655788) AE003715 abd-A-RB abd-A-PB (590 aa) abd-A-RA abd-A-PA (330 aa) specific RNA polymerase II transcription factor activity non-traceable author statement specific RNA polymerase II transcription factor activity anterior/posterior axis specification apoptosis cell growth and/or maintenance germ cell migration gonad development heart development heart proper cell fate commitment (sensu Insecta) mesoderm cell fate specification midgut development neurogenesis oenocyte development peripheral nervous system development regulation of transcription from Pol II promoter specification of segmental identity, abdomen nucleus embryo parasegment 7-13 IPR001356 == Homeobox domain IPR001827 == 'Homeobox' antennapedia-type protein SCOP:46689 == Homeodomain-like; abd-A|FBgn0000014|pp-CT28977|FBan0010325 SCOP:46689 == Homeodomain-like; abd-A|FBgn0000014|pp-CT29034|FBan0010325 DEDB:9540 FlyGRID:FBgn0000014 IFly:../segment/abdmla1.htm KWgx:FBgn0000014 NCBI_GEO:FBgn0000014 FBrf0156093 Christiansen et al. 2002 Trends Genet. 18(10): 510--516 Review FBrf0151731 Duncan 2002 A. Rev. Genet. 36: 521--556 Review FBrf0139881 Mattick and Gagen 2001 Molec. Biol. Evol. 18(9): 1611--1630 Review

The D. melanogaster gene abdominal A, abbreviated as abd-A, is reported here. It encodes a product with specific RNA polymerase II transcription factor activity involved in oenocyte development which is localized to the nucleus; it is expressed in the embryo (ISN, abdominal 4-7 vental intersegmental neuron, amnioserosa, anterior and 18 other listed tissues) and larva (dorsal mesothoracic disc, female genital disc and male genital disc). It has been sequenced and its amino acid sequence contains a homeobox domain and a 'Homeobox' antennapedia-type domain. It has been mapped by recombination to 3-58.8 and cytologically to 89E2. It interacts genetically with su(Hw), Ubx, Abd-B, Dfd, lab and 5 other listed genes. There are 86 recorded alleles: 11 in vitro constructs (1 available from the public stock centers), 74 classical mutants (7 available from the public stock centers) and 1 wild-type. Amorphic mutations have been isolated which affect the midgut constriction, the parasegment 7 to 9, the parasegment 10 to 13 and 11 other listed tissues and are homeotic recessive lethal. abd-A is discussed in 449 references (excluding sequence accessions), dated between 1963 and 2004. These include at least 22 studies of mutant phenotypes, 18 studies of wild-type function, 3 studies of natural polymorphisms and 49 molecular studies. Among findings on abd-A mutants, recessive mutations of the Hab group of abd-A alleles have been isolated as revertants of a dominant gain-of-function abd-A mutation. Among findings on abd-A function, a burst of abd-A expression in the postembryonic neuroblasts specifies the time at which apoptosis occurs, determining the number of progeny generated by each neuroblast. (However, there is much more information on function so that may not be representative.)

FlyBase Gene Summary FBgn0003090 pk prickle Drosophila melanogaster CG12830 CG11084 CG12830 sple pk-sple prickle-spiny-legs prickle-spiny legs Pk-Sple spiny legs 20 Aug 04 2R 2211604..2284282 AE003842 pk-RC pk-PC (1299 aa) pk-RB pk-PB (1029 aa) pk-RA pk-PA (963 aa) protein binding non-traceable author statement structural constituent of cytoskeleton inferred from electronic annotation structural constituent of cytoskeleton protein binding establishment and/or maintenance of cell polarity establishment of ommatidial polarity (sensu Drosophila) establishment of planar polarity establishment of protein localization establishment of wing hair orientation gametogenesis maintenance of protein localization protein localization cytoplasm membrane embryo cephalic furrow larva ventral midline morphogenetic furrow pupa imaginal disc SCOP:57716 == Glucocorticoid receptor-like (DNA-binding domain); pk|FBgn0003090|pp-CT42406|FBan0011084 DEDB:13361 FlyGRID:FBgn0003090 Hybrigenics:522691 IFly:../dbzhnsky/prickl1.htm NCBI_GEO:FBgn0003090 FBrf0156094 Mlodzik 2002 Trends Genet. 18(11): 564--571 Review FBrf0156198 Tree et al. 2002 Semin. Cell Dev. Biol. 13(3): 217--224 Review FBrf0127237 Mlodzik 2000 BioEssays 22(4): 311--315 Review

The D. melanogaster gene prickle, abbreviated as pk, is reported here. It has also been known in FlyBase as CG11084, CG12830 and sple. It encodes a product with protein binding involved in establishment and/or maintenance of cell polarity which is a component of the membrane; it is expressed in the embryo (cephalic furrow and ventral midline), larva (dorsal mesothoracic disc, eye disc, imaginal disc and morphogenetic furrow) and prepupa and pupa (leg and wing). It has been sequenced. It has been mapped by recombination to 2-55.3 and cytologically to 43A1--2. It interacts genetically with Vang, dsh, fz, N, Rac1 and 5 other listed genes. There are 84 recorded alleles: 7 in vitro constructs (none available from the public stock centers), 76 classical mutants (6 available from the public stock centers) and 1 wild-type. Amorphic mutations have been isolated which affect the ectopic joint, the leg, the trichome and 8 other listed tissues and are tissue polarity, recessive visible and somatic clone (with pkpk-sple-13) tissue polarity. pk is discussed in 120 references (excluding sequence accessions), dated between 1944 and 2004. These include at least 12 studies of mutant phenotypes, 4 studies of wild-type function and 5 molecular studies. Among findings on pk function, pk is required for a feedback loop that generates asymmetric planar cell polarity signalling in the wing.

FlyBase Gene Summary FBgn0004644 hh hedgehog Drosophila melanogaster CG4637 l(3)hh l(3)neo56 bar-3: bar-on-3 bar bar3 hg Mrt: Moonrat Hh anon-WO0182946.19 Mir l(3)neo57 bar-3 Moonrat Mrt Mirabile bar-on-3 20 Aug 04 3R complement(18944547..18958373) AE003742 hh-RA hh-PA (471 aa) smoothened binding inferred from genetic interaction with FLYBASE:smo; FB:FBgn0003444 patched binding traceable author statement smoothened binding traceable author statement patched binding non-traceable author statement signal transducer activity traceable author statement morphogen activity traceable author statement cysteine-type endopeptidase activity ; ; EC:3.4.22.- inferred from sequence similarity endopeptidase activity non-traceable author statement morphogen activity signal transducer activity endopeptidase activity cysteine-type endopeptidase activity ; ; EC:3.4.22.- patched binding smoothened binding Bolwig's organ morphogenesis R8 cell fate specification analia morphogenesis (sensu Holometabola) anterior/posterior lineage restriction, imaginal disc cell-cell signaling compartment specification compound eye morphogenesis (sensu Drosophila) determination of anterior/posterior axis, embryo ectoderm development epidermis development foregut morphogenesis genital disc development germ cell attraction germ-line stem cell renewal glia cell migration growth heart development hindgut morphogenesis imaginal disc growth imaginal disc pattern formation intracellular signaling cascade leg disc metamorphosis mesoderm development negative regulation of proteolysis and peptidolysis ovarian follicle cell development (sensu Insecta) pigmentation positive regulation of smoothened receptor signaling pathway progression of morphogenetic furrow (sensu Drosophila) protein autoprocessing protein splicing protein-nucleus import regulation of cell proliferation regulation of mitotic cell cycle regulation of organ size regulation of protein-nucleus import : regulation of transcription from Pol II promoter segment polarity determination smoothened receptor signaling pathway somatic stem cell renewal stalk formation tracheal cell migration (sensu Insecta) tracheal system development (sensu Insecta) wing disc anterior/posterior pattern formation wing disc proximal/distal pattern formation wing vein specification cytoplasm cytoplasmic vesicle extracellular nucleus plasma membrane embryo embryonic/larval hindgut maxillary segment embryonic/larval posterior spiracle embryonic/larval anterior spiracle anal pad embryonic/larval foregut embryonic/larval pharynx embryonic/larval oesophagus larva embryonic/larval hindgut IPR000320 == Hedgehog amino-terminal signaling domain IPR001657 == Sonic hedgehog protein IPR001767 == Hint module SCOP:51294 == Hedgehog/intein (Hint) domain; hh|FBgn0004644|pp-CT14986|FBan0004637 SCOP:55166 == Hedgehog/DD-pepidase; hh|FBgn0004644|pp-CT14986|FBan0004637 DEDB:10274 FlyGRID:FBgn0004644 Hybrigenics:521240 IFly:../segment/hedghog1.htm NCBI_GEO:FBgn0004644 FBrf0159232 Gonzalez-Gaitan 2003 Nature Rev. Molec. Cell. Biol. 4(3): 213--224 Review FBrf0158727 de Celis 2003 BioEssays 25(5): 443--451 Review FBrf0152334 Burtis 2002 Science 297(5584): 1135--1136 Review FBrf0151249 Cripps and Olson 2002 Dev. Biol. 246(1): 14--28 Review FBrf0144824 Frankfort and Mardon 2002 Development 129(6): 1295--1306 Review FBrf0156092 Galis et al. 2002 Trends Genet. 18(10): 504--509 Review FBrf0151999 Jiang 2002 Genes Dev. 16(18): 2315--2321 Review FBrf0155987 Lin 2002 Nature Rev. Genet. 3(12): 931--940 Review FBrf0159733 Nybakken 2002 Curr. Opin. Genet. Dev. 12(5): 503--511 Review FBrf0151798 Nybakken and Perrimon 2002 Biochim. biophys. Acta 1573(3): 280--291 Review FBrf0155653 Peters 2002 Curr. Opin. Neurobiol. 12(1): 43--48 Review FBrf0151324 Seto et al. 2002 Genes Dev. 16(11): 1314--1336 Review FBrf0155675 Vincent and Dubois 2002 Dev. Cell 3(5): 615--623 Review

The D. melanogaster gene hedgehog, abbreviated as hh, is reported here. It has also been known in FlyBase as Mir and l(3)neo56. It encodes a product with patched binding involved in progression of morphogenetic furrow (sensu Drosophila) which is a component of the extracellular; it is expressed in the embryo (anal pad, antennal lobe, antennal segment, embryonic/larval anterior spiracle and 13 other listed tissues) and larva (dorsal mesothoracic disc). It has been sequenced and its amino acid sequence contains a hedgehog amino-terminal signaling domain, a sonic hedgehog domain and a hint module. It has been mapped by recombination to 3-81.2 and cytologically to 94E1. It interacts genetically with ptc, ci, fu, amos, brm and 47 other listed genes. There are 144 recorded alleles: 46 in vitro constructs (none available from the public stock centers), 97 classical mutants (9 available from the public stock centers) and 1 wild-type. Amorphic mutations have been isolated which affect the denticle belt and the embryonic epidermis and are embryonic segment polarity recessive lethal. hh is discussed in 1055 references (excluding sequence accessions), dated between 1950 and 2004. These include at least 125 studies of mutant phenotypes, 30 studies of wild-type function and 18 molecular studies. Among findings on hh mutants, hh mutants display segment polarity segmentation defects. Among findings on hh function, hh may act as an attractive guidance cue in germ cell migration in the embryo. (However, there is much more information on function so that may not be representative.)

FlyBase Gene Summary FBgn0010349 Dhc64C Dynein heavy chain 64C Drosophila melanogaster CG7507 CG7507 CG7507 Fs(3)Laborc Lab HMW MAP cytoplasmic dynein heavy chain Fs(3)Lab Dhc Cdhc: Cytoplasmic dynein heavy chain dynein heavy chain cDhc64C DHC dhc64C CD dhc Laborc DHC64C cytoplasmic dynein dynein cDhc Dhc64c cytoplasmic dynenin Dhc64 Fs(3)Sz18 l(3)64Ca Female sterile(3)Laborc Cdhc Cytoplasmic dynein heavy chain 20 Aug 04 3L complement(4785309..4803674) AE003482 Dhc64C-RB Dhc64C-PB (3388 aa) Dhc64C-RA Dhc64C-PA (4639 aa) microtubule motor activity inferred from direct assay motor activity inferred from sequence similarity with EMBL:N39708 structural constituent of cytoskeleton inferred from electronic annotation ATPase activity, coupled inferred from sequence similarity ATPase activity, coupled non-traceable author statement ATPase activity, coupled inferred from direct assay structural constituent of cytoskeleton ATPase activity, coupled motor activity microtubule motor activity cell motility centrosome cycle dendrite morphogenesis fusome organization and biogenesis germ-line cyst formation intracellular protein transport mRNA localization, intracellular microtubule-based movement mitotic spindle orientation mushroom body development oocyte cell fate determination (sensu Insecta) oocyte nucleus migration oogenesis (sensu Insecta) ovarian ring canal formation vesicle-mediated transport cytoplasm cytoplasmic dynein complex fusome microtubule associated complex ring canal (sensu Insecta) adult testis embryo ovary DEDB:2387 FlyGRID:FBgn0010349 Hybrigenics:521782 IFly:../cytoskel/dynein1.htm KWgx:FBgn0010349 NCBI_GEO:FBgn0010349 FBrf0159339 Gao and Bogert 2003 Trends Neurosci. 26(5): 262--268 Review FBrf0158831 Morris 2003 Curr. Opin. Cell Biol. 15(1): 54--59 Review FBrf0155474 Cohen 2002 Curr. Biol. 12(23): R797--R799 Review

The D. melanogaster gene Dynein heavy chain 64C, abbreviated as Dhc64C, is reported here. It has also been known in FlyBase as Cdhc and Fs(3)Lab. It encodes a product with microtubule motor activity involved in oogenesis (sensu Insecta) which is a component of the microtubule associated complex; it is expressed in the adult (ovary and testis). It has been sequenced and its amino acid sequence is also available. It has been mapped by recombination to 3-10 and cytologically to 64C1. It interacts genetically with Gl, Khc, Lis-1, Klc and CycB. There are 37 recorded alleles: 9 in vitro constructs (none available from the public stock centers), 27 classical mutants (2 available from the public stock centers) and 1 wild-type. Loss-of-function mutations have been isolated which affect the (with Dhc64C6-10) ommatidium, the oocyte, the fusome and the spindle and are recessive lethal. Dhc64C is discussed in 115 references (excluding sequence accessions), dated between 1989 and 2004. These include at least 7 studies of mutant phenotypes, 7 studies of wild-type function and 3 molecular studies. Among findings on Dhc64C mutants, mutations in Dhc64C disrupt fast organelle transport in both directions in axons. Among findings on Dhc64C function, Dhc64C may be involved in the prevention of centrosome assembly in unfertilized eggs, and establishing harmony between the chromosome and centrosome cycles.

FlyBase Gene Summary FBgn0003716 tkv thickveins Drosophila melanogaster CG14026 CG14026 str Brk25D: BMP receptor kinase 25D dtfr l(2)04415 Atkv thick veins Brk25D1 Brk25D2 Tkv Atr25D: Activin-A-receptor-25D Dtfr STK-A l(2)25Da BMP receptor kinase 25D Brk25D slater Activin-A-receptor-25D 20 Aug 04 2L complement(5211567..5263924) AE003609 tkv-RD tkv-PD (509 aa) tkv-RB tkv-PB (531 aa) tkv-RC tkv-PC (575 aa) tkv-RA tkv-PA (563 aa) protein kinase activity ; ; EC:2.7.1.37 non-traceable author statement type I transforming growth factor beta receptor activity inferred from sequence similarity type I transforming growth factor beta receptor activity non-traceable author statement protein kinase activity ; ; EC:2.7.1.37 transforming growth factor beta binding type I transforming growth factor beta receptor activity transforming growth factor beta binding inferred from physical interaction with FLYBASE:dpp; FB:FBgn0000490 type I transforming growth factor beta receptor activity inferred from physical interaction with FLYBASE:dpp; FB:FBgn0000490 BMP signaling pathway anterior/posterior pattern formation, imaginal disc branch cell fate determination (sensu Insecta) branching morphogenesis compound eye morphogenesis (sensu Drosophila) dorsal closure heart development negative regulation of salivary gland determination ovarian follicle cell development (sensu Insecta) positive regulation of synaptic growth at neuromuscular junction protein amino acid phosphorylation tracheal system development (sensu Insecta) transforming growth factor beta receptor complex assembly transforming growth factor beta receptor signaling pathway wing morphogenesis plasma membrane embryo tracheal placode epidermis mesoderm visceral mesoderm tracheal pit embryonic/larval midgut posterior midgut primordium anterior midgut primordium midgut constriction 1 midgut constriction 4 nurse cell ectoderm anterior embryonic/larval midgut posterior embryonic/larval midgut embryonic/larval pharynx gastric caecum embryonic/larval hindgut embryonic/larval proventriculus midgut chamber 1 larva dorsal mesothoracic disc neurectoderm oogenesis, adult centripetally migrating follicle cell IPR000472 == TGF-&bgr; receptor family, extracellular domain/Activin types I and II receptor domain IPR000719 == Eukaryotic protein kinase IPR002290 == Serine/Threonine protein kinase family active site IPR003605 == GS motif preceding kinase domain in TGF &bgr; receptor SCOP:56112 == Protein kinase-like (PK-like); tkv|FBgn0003716|pp-CT33585|FBan0014026 SCOP:57302 == Snake toxin-like; tkv|FBgn0003716|pp-CT33585|FBan0014026 BDGPisx:tkv DEDB:6478 FlyGRID:FBgn0003716 IFly:../gene/thickvan.htm KWgx:FBgn0003716 NCBI_GEO:FBgn0003716 FBrf0151249 Cripps and Olson 2002 Dev. Biol. 246(1): 14--28 Review FBrf0151324 Seto et al. 2002 Genes Dev. 16(11): 1314--1336 Review FBrf0155675 Vincent and Dubois 2002 Dev. Cell 3(5): 615--623 Review

The D. melanogaster gene thickveins, abbreviated as tkv, is reported here. It has also been known in FlyBase as l(2)04415. It encodes a product with type I transforming growth factor beta receptor activity involved in tracheal system development (sensu Insecta) which is a component of the plasma membrane; it is expressed in the embryo (anterior embryonic/larval midgut, anterior midgut primordium, ectoderm, embryonic/larval hindgut and 16 other listed tissues), larva (dorsal mesothoracic disc, eye-antennal disc, imaginal disc, morphogenetic furrow and ventral thoracic disc) and ovary (centripetally migrating follicle cell and nurse cell). It has been sequenced and its amino acid sequence contains a TGF-&bgr; receptor family, extracellular domain/Activin types I and II receptor domain, an eukaryotic protein kinase, a serine/Threonine protein kinase family active site and a GS motif preceding kinase domain in TGF &bgr; receptor. It has been mapped by recombination to 2-16 and cytologically to 25D1--2. It interacts genetically with dpp, Mad, sax, shn, put and 33 other listed genes. There are 67 recorded alleles: 40 in vitro constructs (none available from the public stock centers), 26 classical mutants (6 available from the public stock centers) and 1 wild-type. Amorphic mutations have been isolated which affect the maternal effect abdominal 1 to 7 ventral denticle belt, the maternal effect metathoracic ventral denticle belt, the maternal effect mesothoracic ventral denticle belt and 12 other listed tissues and are embryonic maternal effect lethal and recessive somatic clone cell lethal. tkv is discussed in 382 references (excluding sequence accessions), dated between 1980 and 2004. These include at least 49 studies of mutant phenotypes, 5 studies of wild-type function and 12 molecular studies.

FlyBase Gene Summary FBgn0003205 Ras85D Ras oncogene at 85D Drosophila melanogaster CG9375 Dmras85D D-ras-1 Dras1 E(sev)3C Ras1 p21<up>Ras1</up> Su(tor)3-2 ras1 Ras Ras-1 l(3)06677 Draf-1 ras D-Ras RAS1 E(faf) D-Ras1 DRas Dras85D RAS D-ras1 RTK RasI Dras ras85B dRAS1 ras85D dRas1 EK3-4 ras 1 DRAS1 DRas85D/Ras dras1 S35097 Dm Ras1 C-ras1 fs(3)05703 l(3)s1747 Enhancer of faf 20 Aug 04 3R complement(5336289..5338802) AE003683 Ras85D-RA Ras85D-PA (189 aa) GDP binding non-traceable author statement GTPase activity GTPase activity non-traceable author statement GTPase activity inferred from sequence similarity GDP binding GTPase activity inferred from sequence similarity with MGD:Kras2; MGI:MGI:96680 G-protein coupled receptor protein signaling pathway G1/S transition of mitotic cell cycle anti-apoptosis border cell migration (sensu Insecta) cell fate specification cell growth cytoskeleton organization and biogenesis determination of anterior/posterior axis, embryo dorsal closure eggshell pattern formation (sensu Insecta) eye morphogenesis (sensu Drosophila) heart development intracellular protein transport muscle contraction negative regulation of retinal programmed cell death (sensu Drosophila) oncogenesis ovarian follicle cell development (sensu Insecta) perineurial glial growth positive regulation of cell growth primary tracheal branching (sensu Insecta) receptor mediated endocytosis regulation of cell growth regulation of exocytosis regulation of growth sevenless signaling pathway synaptic transmission torso signaling pathway wing disc metamorphosis wing morphogenesis adult genital disc embryo dorsal mesothoracic disc larva eye-antennal disc oogenesis oocyte IPR001806 == Ras GTPase superfamily IPR003577 == RAS small GTPases, Ras subfamily SCOP:52540 == P-loop containing nucleotide triphosphate hydrolases; Ras85D|FBgn0003205|pp-CT26623|FBan0009375 DEDB:8653 FlyGRID:FBgn0003205 Hybrigenics:521453 IFly:../torstoll/ras85-1.htm NCBI_GEO:FBgn0003205 FBrf0147184 Gorski and Marra 2002 Physiol. Genomics 9(2): 59--69 Review FBrf0149068 Richardson and Kumar 2002 J. Immunol. Methods 265(1-2): 21--38 Review FBrf0144793 White 2002 Dev. Cell 2(2): 128--130 Review

The D. melanogaster gene Ras oncogene at 85D, abbreviated as Ras85D, is reported here. It has also been known in FlyBase as l(3)06677. It encodes a product with GDP binding involved in torso signaling pathway which is expressed in the adult (abdominal ganglion, adult brain and thoracic ganglion), larva (dorsal mesothoracic disc, embryonic/larval brain, eye-antennal disc and genital disc) and ovary (oocyte). It has been sequenced and its amino acid sequence contains a ras GTPase superfamily and a RAS small GTPases, Ras subfamily. It has been mapped by recombination to 3-50 and cytologically to 85D21. It interacts genetically with rl, S, phl, aop, Egfr and 131 other listed genes. There are 100 recorded alleles: 48 in vitro constructs (5 available from the public stock centers), 51 classical mutants (4 available from the public stock centers) and 1 wild-type. Loss-of-function mutations have been isolated which affect the germ-line clone filzkorper, the embryonic abdominal segment 8, the somatic clone imaginal disc and 6 other listed tissues and are somatic clone mitotic. Ras85D is discussed in 520 references (excluding sequence accessions), dated between 1984 and 2004. These include at least 118 studies of mutant phenotypes, 9 studies of wild-type function, 2 studies of natural polymorphisms and 11 molecular studies. Among findings on Ras85D function, Ras85D controls growth, survival and differentiation in the eye.

FlyBase Gene Summary FBgn0000183 BicD Bicaudal D Drosophila melanogaster CG6605 Bic-D Bic<up>D</up> BIC-D Bicaudal-D anon-EST:fe2A11 anon-fast-evolving-2A11 21 Aug 04 2L complement(17438917..17451338) AE003655 BicD-RA BicD-PA (782 aa) chromatin binding dynein binding non-traceable author statement NOT RNA binding non-traceable author statement chromatin binding inferred from electronic annotation dynein binding NOT RNA binding NOT female germ-line cyst formation (sensu Insecta) cell differentiation egg chamber formation (sensu Insecta) mRNA localization, intracellular mitosis oocyte anterior/posterior axis determination (sensu Insecta) oocyte axis determination oocyte cell fate determination (sensu Insecta) oocyte dorsal/ventral axis determination (sensu Insecta) oocyte microtubule cytoskeleton organization (sensu Insecta) oocyte microtubule cytoskeleton organization oocyte microtubule cytoskeleton polarization oocyte nucleus migration (sensu Insecta) oogenesis (sensu Insecta) microtubule cytoskeleton embryo ovary oogenesis, adult ovary germarium region 1..3 nurse cell oocyte BDGPisx:BicD DEDB:7846 FlyGRID:FBgn0000183 Hybrigenics:522131 IFly:../cytoskel/bicauld1.htm KWgx:FBgn0000183 NCBI_GEO:FBgn0000183 FBrf0156097 Tekotte and Davis 2002 Trends Genet. 18(12): 636--642 Review FBrf0132360 Deng and Lin 2001 Etkin, Jeon, 2001: 93--138 Review FBrf0141280 Johnstone and Lasko 2001 A. Rev. Genet. 35: 365--406 Review FBrf0132358 Mahowald 2001 Etkin, Jeon, 2001: 187--213 Review FBrf0144751 Saxton 2001 Cell 107(6): 707--710 Review

The D. melanogaster gene Bicaudal D, abbreviated as BicD, is reported here. It has also been known in FlyBase as anon-EST:fe2A11 and anon-fe2A11. It encodes a product with dynein binding involved in oogenesis (sensu Insecta) which is localized to the cytoplasm; it is expressed in the adult (ovary) and ovary (cystocyte, germarium region 1 to 3, nurse cell, oocyte and 2 other listed tissues). It has been sequenced and its amino acid sequence is also available. It has been mapped by recombination to 2-52.91 and cytologically to 36C9. It interacts genetically with egl, kst, bic, RpII140, vas and 6 other listed genes. There are 26 recorded alleles: 9 in vitro constructs (none available from the public stock centers), 16 classical mutants (3 available from the public stock centers) and 1 wild-type. Amorphic mutations have been isolated which affect the egg chamber and the nurse cell ring canal and are recessive lethal and uncoordinated. BicD is discussed in 188 references (excluding sequence accessions), dated between 1982 and 2004. These include at least 23 studies of mutant phenotypes, 2 studies of wild-type function and 8 molecular studies. Among findings on BicD mutants, none of the cells in the female germline cyst form synaptonemal complex in BicD null mutants. Among findings on BicD function, BicD is required for the formation of and cytoskeletal organization of the egg chamber.

FlyBase Gene Summary FBgn0000273 Pka-C1 cAMP-dependent protein kinase 1 Drosophila melanogaster CG4379 CG4379 DC0 dco dcO PKA Pka DCO pka protein kinase A Dco pkA pka-C1 l(2)01272 C: Group C PKAc Dc0 PKA-C1 6353 pKA Pka-C Protein Kinase A PKA Cl PKAcA dPKA CdkA Dcpk l(2)s4402 C 20 Aug 04 2L complement(9676885..9691522) AE003625 Pka-C1-RC Pka-C1-PC (353 aa) Pka-C1-RB Pka-C1-PB (353 aa) Pka-C1-RA Pka-C1-PA (353 aa) receptor signaling protein serine/threonine kinase activity ; ; EC:2.7.1.- inferred from electronic annotation protein serine/threonine kinase activity non-traceable author statement cAMP-dependent protein kinase activity inferred from sequence similarity cAMP-dependent protein kinase activity non-traceable author statement protein serine/threonine kinase activity receptor signaling protein serine/threonine kinase activity ; ; EC:2.7.1.- cAMP-dependent protein kinase activity anterior/posterior pattern formation, imaginal disc behavioral response to ethanol cAMP-mediated signaling eye morphogenesis (sensu Drosophila) learning learning and/or memory leg morphogenesis (sensu Holometabola) locomotor rhythm memory olfactory learning oocyte anterior/posterior axis determination oocyte microtubule cytoskeleton polarization oogenesis (sensu Insecta) protein amino acid phosphorylation regulation of bicoid mRNA localization regulation of pole plasm oskar mRNA localization rhythmic behavior wing morphogenesis cAMP-dependent protein kinase complex plasma membrane adult mushroom body oogenesis, adult germarium IPR000719 == Eukaryotic protein kinase IPR000961 == Protein kinase C-terminal domain IPR002290 == Serine/Threonine protein kinase family active site SCOP:56112 == Protein kinase-like (PK-like); Pka-C1|FBgn0000273|pp-CT14278|FBan0004379 DEDB:6995 FlyGRID:FBgn0000273 IFly:../newgene/pka-c1.htm NCBI_GEO:FBgn0000273 FBrf0155881 Stanewsky 2003 J. Neurobiol. 54(1): 111--147 Review FBrf0151999 Jiang 2002 Genes Dev. 16(18): 2315--2321 Review FBrf0155655 Rothenfluh and Heberlein 2002 Curr. Opin. Neurobiol. 12(6): 639--645 Review FBrf0151232 Stanewsky 2002 Cell Tissue Res. 309(1): 11--26 Review

The D. melanogaster gene cAMP-dependent protein kinase 1, abbreviated as Pka-C1, is reported here. It encodes a product with protein serine/threonine kinase activity involved in oocyte anterior/posterior axis determination which is a component of the plasma membrane; it is expressed in the adult (alpha-lobe, beta-lobe, gamma-lobe, adult brain and 7 other listed tissues), larva (dorsal mesothoracic disc and larval brain) and ovary (germarium, nurse cell and oocyte). It has been sequenced and its amino acid sequence contains an eukaryotic protein kinase, a protein kinase C-terminal domain and a serine/Threonine protein kinase family active site. It has been mapped cytologically to 30C5. It interacts genetically with dpp, hh, ci, Su(fu), wg and 7 other listed genes. There are 46 recorded alleles: 10 in vitro constructs (none available from the public stock centers), 35 classical mutants (3 available from the public stock centers) and 1 wild-type. Amorphic mutations have been isolated which affect the oocyte, the germ-line clone nurse cell, the germ-line clone egg chamber and 13 other listed tissues and are recessive lethal, female sterile and dominant chemical sensitive. Pka-C1 is discussed in 280 references (excluding sequence accessions), dated between 1984 and 2004. These include at least 31 studies of mutant phenotypes, 2 studies of wild-type function and 15 molecular studies. Among findings on Pka-C1 function, Pka-C1 plays a critical role in the flow of temporal information from circadian pacemaker cells to specific downstream targets controlling overt behaviors.

FlyBase Gene Summary FBgn0000533 ea easter Drosophila melanogaster CG4920 CG4920 c-SP24 SP24 20 Aug 04 3R 11154470..11156153 AE003708 ea-RA ea-PA (392 aa) serine-type peptidase activity non-traceable author statement peptidase activity ; ; EC:3.4.-.- traceable author statement serine-type endopeptidase activity ; ; EC:3.4.21.- non-traceable author statement trypsin activity ; ; EC:3.4.21.4 non-traceable author statement monophenol monooxygenase activator activity inferred from sequence similarity serine-type endopeptidase activity ; ; EC:3.4.21.- inferred from direct assay peptidase activity ; ; EC:3.4.-.- non-traceable author statement serine-type endopeptidase activity ; ; EC:3.4.21.- serine-type peptidase activity peptidase activity ; ; EC:3.4.-.- trypsin activity ; ; EC:3.4.21.4 monophenol monooxygenase activator activity Toll signaling pathway defense response dorsal/ventral axis specification maternal determination of dorsal/ventral axis, oocyte, germ-line encoded proteolysis and peptidolysis extracellular oogenesis, adult ovary IPR001254 == Serine proteases, trypsin family IPR001314 == Chymotrypsin serine protease family (S1) IPR001827 == 'Homeobox' antennapedia-type protein SCOP:50494 == Trypsin-like serine proteases; ea|FBgn0000533|pp-CT15808|FBan0004920 DEDB:9330 FlyGRID:FBgn0000533 KWgx:FBgn0000533 NCBI_GEO:FBgn0000533 FBrf0148941 Stathopoulos and Levine 2002 Dev. Biol. 246(1): 57--67 Review FBrf0141281 Lall and Patel 2001 A. Rev. Genet. 35: 407--437 Review FBrf0123023 Govind 1999 Oncogene 18(49): 6875--6887 Review FBrf0107848 LeMosy et al. 1999 Trends Cell Biol. 9(3): 102--107 Review

The D. melanogaster gene easter, abbreviated as ea, is reported here. It encodes a product with trypsin activity (EC:3.4.21.4) involved in dorsal/ventral axis specification which is a component of the extracellular; it is expressed in the ovary (ovary). It has been sequenced and its amino acid sequence contains a serine proteases, trypsin family, a chymotrypsin serine protease family (S1) and a 'Homeobox' antennapedia-type domain. It has been mapped by recombination to 3-57 and cytologically to 88F1. It interacts genetically with cact, Tl, tkv, put, shn and 3 other listed genes. There are 79 recorded alleles: 20 in vitro constructs (none available from the public stock centers), 58 classical mutants (2 available from the public stock centers) and 1 wild-type. Amorphic mutations have been isolated which affect the embryonic epidermis and are maternal effect dominant lethal. ea is discussed in 128 references (excluding sequence accessions), dated between 1984 and 2004. These include at least 13 studies of mutant phenotypes, 2 studies of wild-type function and 6 molecular studies. Among findings on ea function, ea is not required for muscle development in the embryo.

FlyBase Gene Summary FBgn0004859 ci cubitus interruptus Drosophila melanogaster CG2125 CG2125 l(4)13 l(4)17 ci-D: cubitus-interruptus-dominant ci<up>D</up> Ce: Cell Ci<up>D</up> cubitus-interruptus-Dominant CiD ciD CID Ci Cubitus interruptus ci155 l(4)102ABc ci-D Ce cubitus-interruptus-dominant Cell 20 Aug 04 4 complement(68334..77667) AE003845 ci-RA ci-PA (1397 aa) specific RNA polymerase II transcription factor activity non-traceable author statement transcription factor activity traceable author statement transcriptional activator activity traceable author statement transcriptional repressor activity traceable author statement transcription factor activity specific RNA polymerase II transcription factor activity transcriptional activator activity transcriptional repressor activity blastoderm segmentation genital disc anterior/posterior pattern formation negative regulation of transcription from Pol II promoter ovarian follicle cell development (sensu Insecta) positive regulation of transcription from Pol II promoter regulation of mitotic cell cycle regulation of transcription smoothened receptor signaling pathway cytoplasm nucleus embryo ectoderm mesoderm embryonic/larval foregut embryonic central nervous system mesectoderm segmantally repeated larva imaginal disc IPR000822 == Zinc finger, C2H2 type SCOP:57667 == C2H2 and C2HC zinc fingers; ci|FBgn0004859|pp-CT6641|FBan0002125 DEDB:13428 FlyGRID:FBgn0004859 Hybrigenics:521395 Hybrigenics:521465 IFly:../segment/cubitus.htm NCBI_GEO:FBgn0004859 FBrf0158727 de Celis 2003 BioEssays 25(5): 443--451 Review FBrf0151731 Duncan 2002 A. Rev. Genet. 36: 521--556 Review FBrf0156092 Galis et al. 2002 Trends Genet. 18(10): 504--509 Review FBrf0151999 Jiang 2002 Genes Dev. 16(18): 2315--2321 Review FBrf0155667 Jin and Harper 2002 Dev. Cell 2(6): 685--687 Review FBrf0151324 Seto et al. 2002 Genes Dev. 16(11): 1314--1336 Review

The D. melanogaster gene cubitus interruptus, abbreviated as ci, is reported here. It encodes a product with transcriptional activator activity involved in smoothened receptor signaling pathway which is a component of the nucleus; it is expressed in the embryo (ectoderm, embryonic central nervous system, embryonic/larval foregut, embryonic/larval hindgut and 3 other listed tissues) and larva (female genital disc, imaginal disc and male genital disc). It has been sequenced and its amino acid sequence contains a zinc finger, C2H2 type. It has been mapped by recombination to 4-0.0 and cytologically to 102A1--3. It interacts genetically with en, hh, cg, ptc, Pka-C1 and 21 other listed genes. There are 155 recorded alleles: 119 in vitro constructs (none available from the public stock centers), 35 classical mutants (8 available from the public stock centers) and 1 wild-type. Amorphic mutations have been isolated which affect the wing, the wing vein L4, the mesothoracic tarsal bristle longitudinal row 1 and 8 other listed tissues and are recessive lethal, dominant visible and pupal (with cin) lethal. ci is discussed in 552 references (excluding sequence accessions), dated between 1931 and 2004. These include at least 56 studies of mutant phenotypes, 8 studies of wild-type function, 4 studies of natural polymorphisms and 23 molecular studies. Among findings on ci mutants, late ptc transcription patterns depend upon selective repression by ciD. Among findings on ci function, characterization of ci protein reveals it exists in at least two forms, one full-length and the other truncated, these forms differ in activity and subcellular location.

FlyBase Gene Summary FBgn0003483 spn-E spindle E Drosophila melanogaster CG3158 fs(1)hls hls: homeless homeless spn-E/hls spnE spn E Homeless Spindle E spindle-E Spn-E fs(3)hls hls female sterile(3)homeless 20 Aug 04 3R 11663177..11670156 AE003710 spn-E-RA spn-E-PA (1434 aa) nucleic acid binding RNA helicase activity ; ; EC:2.7.7.- traceable author statement helicase activity inferred from sequence similarity nucleic acid binding inferred from electronic annotation RNA helicase activity ; ; EC:2.7.7.- helicase activity ATP-dependent RNA helicase activity RNA-dependent ATPase activity ATP-dependent RNA helicase activity inferred from sequence similarity with InterPro:IPR001410 RNA-dependent ATPase activity traceable author statement RNA interference RNA interference, targeting of mRNA for destruction RNA localization chromatin silencing karyosome formation mRNA localization, intracellular nuclear mRNA splicing, via spliceosome oocyte cell fate determination (sensu Insecta) oocyte differentiation oocyte maturation oocyte positioning oogenesis (sensu Insecta) polarity specification of anterior/posterior axis polarity specification of dorsal/ventral axis pole plasm assembly pole plasm oskar mRNA localization regulation of pole plasm oskar mRNA localization cytoplasm embryo germarium oogenesis, adult ovary nurse cell IPR000822 == Zinc finger, C2H2 type IPR001410 == DEAD/DEAH box helicase IPR001650 == Helicase C-terminal domain IPR002999 == Tudor domain SCOP:52540 == P-loop containing nucleotide triphosphate hydrolases; spn-E|FBgn0003483|pp-CT10340|FBan0003158 DEDB:9405 FlyGRID:FBgn0003483 IFly:../dbzhnsky/homels1.htm NCBI_GEO:FBgn0003483 FBrf0150772 Schwarz and Zamore 2002 Genes Dev. 16(9): 1025--1031 Review FBrf0132360 Deng and Lin 2001 Etkin, Jeon, 2001: 93--138 Review FBrf0141280 Johnstone and Lasko 2001 A. Rev. Genet. 35: 365--406 Review

The D. melanogaster gene spindle E, abbreviated as spn-E, is reported here. It has also been known in FlyBase as fs(3)hls. It encodes a product with RNA-dependent ATPase activity involved in karyosome formation which is a component of the cytoplasm; it is expressed in the ovary (female germline stem cell, germarium, nurse cell and ovary). It has been sequenced and its amino acid sequence contains a zinc finger, C2H2 type, a DEAD/DEAH box helicase, a helicase C-terminal domain and a tudor domain. It has been mapped by recombination to 3-62 and cytologically to 89A5. It interacts genetically with spn-B and spn-D. There are 20 recorded alleles: 1 in vitro construct (not available from the public stock centers), 18 classical mutants (1 available from the public stock centers) and 1 wild-type. Amorphic mutations have been isolated which affect the dorsal appendage and the egg chamber and are female sterile and male fertile. spn-E is discussed in 54 references (excluding sequence accessions), dated between 1987 and 2004. These include at least 4 studies of mutant phenotypes, 3 studies of wild-type function and 3 molecular studies. Among findings on spn-E mutants, spn-E mutants block RNAi activation which normally occurs during egg maturation.

FlyBase Gene Summary FBgn0000250 cact cactus Drosophila melanogaster CG5848 CG5848 CG5848 cac fs(2)ltoRN48 BG:DS02740.15 n(2)k17003 dip6 female-sterile-(2)-ltoRN48 20 Aug 04 2L complement(16291113..16304185) AE003650 cact-RD cact-PD (500 aa) cact-RC cact-PC (482 aa) cact-RB cact-PB (500 aa) cact-RA cact-PA (500 aa) transcription factor binding transcription factor binding traceable author statement transcription regulator activity inferred from electronic annotation transcription regulator activity protein binding protein binding inferred from physical interaction with FLYBASE:ird5; FB:FBgn0024222 I-kappaB kinase/NF-kappaB cascade Toll signaling pathway anti-apoptosis antifungal humoral response (sensu Protostomia) antifungal polypeptide induction antimicrobial humoral response (sensu Protostomia) cellular defense response cytoplasmic sequestering of transcription factor defense response dorsal appendage formation dorsal/ventral axis specification hemopoiesis immune response negative regulation of protein-nucleus import oogenesis (sensu Insecta) regulation of transcription from Pol II promoter response to fungi cytoplasm SCOP:48403 == Ankyrin repeat; cact|FBgn0000250|pp-CT18347|FBan0005848 DEDB:7745 FlyGRID:FBgn0000250 Hybrigenics:521336 IFly:../torstoll/cactus1.htm KWgx:FBgn0000250 NCBI_GEO:FBgn0000250 FBrf0149180 Khush et al. 2002 Science 296: 273--275 Review FBrf0156068 Imler and Hoffmann 2001 Trends Cell Biol. 11(7): 304--311 Review FBrf0141281 Lall and Patel 2001 A. Rev. Genet. 35: 407--437 Review FBrf0139665 Silverman and Maniatis 2001 Genes Dev. 15(18): 2321--2342 Review

The D. melanogaster gene cactus, abbreviated as cact, is reported here. It has also been known in FlyBase as fs(2)ltoRN48. It encodes a product with transcription factor binding involved in oogenesis (sensu Insecta) which is localized to the cytoplasm. It has been sequenced and its amino acid sequence is also available. It has been mapped by recombination to 2-52 and cytologically to 35F9--11. It interacts genetically with fus, dl, ea, spz, RpII140 and 9 other listed genes. There are 118 recorded alleles: 48 in vitro constructs (none available from the public stock centers), 69 classical mutants (5 available from the public stock centers) and 1 wild-type. Loss-of-function mutations have been isolated which affect the dorsal embryonic epidermis, the germ-line clone embryonic/first instar larval cuticle, the larval hemocyte and 4 other listed tissues and are recessive lethal. cact is discussed in 266 references (excluding sequence accessions), dated between 1987 and 2004. These include at least 32 studies of mutant phenotypes, 5 studies of wild-type function and 20 molecular studies. Among findings on cact mutants, mutations in cact result in a maternal effect phenotype with defects during the early stages of gastrulation and defects in the dorsoventral axis; embryos derived from homozygous females are ventralized. Among findings on cact function, cact acts in a cell-autonomous manner in the fat body.

FlyBase Gene Summary FBgn0004864 hop hopscotch Drosophila melanogaster CG1594 CG1594 4 locus 18 L4 l(1)hop l(1)L4 Tum: Tumorous l(1)10Be Jak Hop Dm JAK JAK DmHD-160 Hop1 Jak-STAT Tum-1 Hopskotch HD-160 l(1)G18 msvl Tum Tumorous 20 Aug 04 X complement(11102838..11110036) AE003485 hop-RA hop-PA (1177 aa) non-membrane spanning protein tyrosine kinase activity ; ; EC:2.7.1.- non-traceable author statement Janus kinase activity ; ; EC:2.7.1.- inferred from sequence similarity with HUGO:JAK1; OMIM:147795 Janus kinase activity ; ; EC:2.7.1.- inferred from sequence similarity with MGD:Jak2; MGI:MGI:96629 Janus kinase activity ; ; EC:2.7.1.- non-traceable author statement Janus kinase activity ; ; EC:2.7.1.- traceable author statement protein-tyrosine kinase activity ; ; EC:2.7.1.112 non-traceable author statement protein-tyrosine kinase activity ; ; EC:2.7.1.112 non-membrane spanning protein tyrosine kinase activity ; ; EC:2.7.1.- Janus kinase activity ; ; EC:2.7.1.- JAK-STAT cascade STAT protein nuclear translocation blastoderm segmentation border cell migration (sensu Insecta) cell proliferation cellular defense response cytokinesis defense response ectoderm development encapsulation of foreign target equator specification establishment of ommatidial polarity (sensu Drosophila) eye morphogenesis (sensu Drosophila) germ-line stem cell renewal hemocyte differentiation (sensu Arthropoda) hemocyte proliferation (sensu Arthropoda) hemopoiesis hindgut morphogenesis humoral immune response immune response lamellocyte differentiation leg morphogenesis (sensu Holometabola) mesoderm development neurogenesis ommatidial rotation oogenesis (sensu Insecta) ovarian follicle cell development (sensu Insecta) periodic partitioning photoreceptor differentiation (sensu Drosophila) primary sex determination protein amino acid phosphorylation sex determination somatic stem cell renewal stem cell maintenance tracheal system development (sensu Insecta) tyrosine phosphorylation of STAT protein wing morphogenesis cytoplasm IPR000719 == Eukaryotic protein kinase IPR000980 == Src homology 2 (SH2) domain IPR001245 == Tyrosine kinase catalytic domain SCOP:56112 == Protein kinase-like (PK-like); Hop|FBgn0024352|pp-CT4219|FBan0001594 DEDB:2463 FlyGRID:FBgn0004864 IFly:../gene/hopscotc.htm KWgx:FBgn0004864 NCBI_GEO:FBgn0004864 FBrf0155682 Silver and Montell 2003 Dev. Cell 4(2): 148--149 Review FBrf0151864 Castelli-Gair Hombria and Brown 2002 Curr. Biol. 12(16): R569--R575 Review FBrf0155676 Hou et al. 2002 Dev. Cell 3(6): 765--778 Review FBrf0155987 Lin 2002 Nature Rev. Genet. 3(12): 931--940 Review

The D. melanogaster gene hopscotch, abbreviated as hop, is reported here. It has also been known in FlyBase as HD-160. It encodes a product with protein-tyrosine kinase activity (EC:2.7.1.112) involved in cytokinesis which is a component of the cytoplasm. It has been sequenced and its amino acid sequence contains an eukaryotic protein kinase, a src homology 2 (SH2) domain and a tyrosine kinase catalytic domain. It has been mapped by recombination to 1-34.6 and cytologically to 10B5--6. It interacts genetically with Stat92E, os, dome, E(hopTum), awd and 8 other listed genes. There are 67 recorded alleles: 13 in vitro constructs (none available from the public stock centers), 53 classical mutants (2 available from the public stock centers) and 1 wild-type. Amorphic mutations have been isolated which affect the germ-line clone segment and are larval maternal effect lethal and (with hop25) viable. hop is discussed in 204 references (excluding sequence accessions), dated between 1971 and 2004. These include at least 23 studies of mutant phenotypes, 8 studies of wild-type function and 3 molecular studies. Among findings on hop mutants, mutations in Jak kinase, hop, can cause leukemia-like abnormalities. Among findings on hop function, hop is required for the renewal of male germline stem cells and for maintenance of the somatic cyst progenitor cell population in the testis.

FlyBase Gene Summary FBgn0000575 emc extra macrochaetae Drosophila melanogaster CG1007 CG1007 Ach: Achetous ms(3)61CD gov 0094/26 0203/10 0587/01 0977/09 l(3)05592 Dm0688 Emc extramacrochaetae l(3)04322 l(3)j4E11 male sterile(3)61CD Ach Achetous golovan 20 Aug 04 3L 729659..734134 AE003469 emc-RA emc-PA (199 aa) protein binding non-traceable author statement transcription corepressor activity non-traceable author statement protein binding transcription corepressor activity transcription corepressor activity inferred from sequence similarity with UniProt:P41137 bristle morphogenesis negative regulation of transcription negative regulation of transcription from Pol II promoter neurogenesis peripheral nervous system development restriction of R8 fate sensory organ development sex determination sex determination, primary response to X:A ratio spermatid development wing vein morphogenesis nucleus embryo imaginal disc stomodeum hindgut primordium Malpighian tubule primordium amnioserosa tracheal pit visceral mesoderm ventral nerve cord procephalic segment embryonic/larval foregut apodeme posterior embryonic/larval midgut Malpighian tubule anterior embryonic/larval midgut larva dorsal mesothoracic disc unfertilized egg ventral midline IPR001092 == Helix-loop-helix dimerization domain IPR003015 == Myc-type, helix-loop-helix dimerization domain SCOP:47459 == Helix-loop-helix DNA-binding domain; emc|FBgn0000575|pp-CT1010|FBan0001007 BDGPisx:emc DEDB:1881 FlyGRID:FBgn0000575 IFly:../gene/emc.htm KWgx:FBgn0000575 NCBI_GEO:FBgn0000575 FBrf0158727 de Celis 2003 BioEssays 25(5): 443--451 Review FBrf0151319 Calleja et al. 2002 Gene 292(1-2): 1--12 Review FBrf0144824 Frankfort and Mardon 2002 Development 129(6): 1295--1306 Review

The D. melanogaster gene extra macrochaetae, abbreviated as emc, is reported here. It has also been known in FlyBase as gov, l(3)05592 and ms(3)61CD. It encodes a product with protein binding involved in neurogenesis which is a component of the nucleus; it is expressed in the embryo (Malpighian tubule, Malpighian tubule primordium, amnioproctodeal invagination, amnioserosa and 25 other listed tissues) and larva (dorsal mesothoracic disc and imaginal disc). It has been sequenced and its amino acid sequence contains a helix-loop-helix dimerization domain and a myc-type, helix-loop-helix dimerization domain. It has been mapped by recombination to 3-0.0 and cytologically to 61C9. It interacts genetically with Dl, N, rho, pyd, bs and 12 other listed genes. There are 77 recorded alleles: 3 in vitro constructs (none available from the public stock centers), 73 classical mutants (5 available from the public stock centers) and 1 wild-type. Amorphic mutations have been isolated which affect the somatic clone wing, the somatic clone mesothoracic tergum, the ectopic sense organ and 2 other listed tissues and are lethal and somatic clone cell lethal. emc is discussed in 207 references (excluding sequence accessions), dated between 1980 and 2004. These include at least 34 studies of mutant phenotypes, 3 studies of wild-type function, one study of natural polymorphisms and 11 molecular studies. Among findings on emc function, emc is required during development of the imaginal wing discs in both cell proliferation and cell differentiation processes.

FlyBase Gene Summary FBgn0011591 fng fringe Drosophila melanogaster CG10580 CG10580 l(3)rG554 D-fng Frg fg: flag frg D-Fng Dfng fg 20 Aug 04 3L complement(20843159..20866785) AE003592 fng-RA fng-PA (412 aa) acetylglucosaminyltransferase activity ; ; EC:2.4.1.- non-traceable author statement UDP-glycosyltransferase activity inferred from direct assay transferase activity, transferring glycosyl groups ; ; EC:2.4.-.- inferred from mutant phenotype transferase activity, transferring glycosyl groups ; ; EC:2.4.-.- traceable author statement acetylglucosaminyltransferase activity ; ; EC:2.4.1.- traceable author statement receptor binding inferred from electronic annotation receptor binding acetylglucosaminyltransferase activity ; ; EC:2.4.1.- transferase activity, transferring glycosyl groups ; ; EC:2.4.-.- UDP-glycosyltransferase activity Notch signaling pathway cell fate specification dorsal/ventral lineage restriction, imaginal disc dorsal/ventral pattern formation, imaginal disc ectoderm development egg chamber formation (sensu Insecta) eye morphogenesis (sensu Drosophila) leg disc metamorphosis negative regulation of Notch signaling pathway neurogenesis oogenesis (sensu Insecta) positive regulation of Notch signaling pathway regulation of Notch signaling pathway segment specification wing margin morphogenesis wing morphogenesis Golgi apparatus Golgi stack endoplasmic reticulum integral to membrane adult, oogenesis follicle cell polar follicle cell follicle cell <of> germarium region 2b larva dorsal mesothoracic disc BDGPisx:fng DEDB:5900 FlyGRID:FBgn0011591 IFly:../newgene/fringe.htm NCBI_GEO:FBgn0011591 FBrf0155573 Haltiwanger and Stanley 2002 Biochim. biophys. Acta 1573(3): 328--335 Review FBrf0151490 Stewart 2002 Semin. Cell Dev. Biol. 13(2): 91--97 Review FBrf0155642 Wilson 2002 Curr. Opin. Struct. Biol. 12(5): 569--577 Review

The D. melanogaster gene fringe, abbreviated as fng, is reported here. It has also been known in FlyBase as l(3)rG554. It encodes a product with UDP-glycosyltransferase activity involved in wing morphogenesis which is localized to the Golgi apparatus; it is expressed in the adult (follicle cell and polar follicle cell) and larva (dorsal mesothoracic disc). It has been sequenced and its amino acid sequence is also available. It has been mapped by recombination to 3-47 and cytologically to 78A1. It interacts genetically with Ser, ap, N, Bx, Dl and 5 other listed genes. There are 53 recorded alleles: 22 in vitro constructs (1 available from the public stock centers), 30 classical mutants (1 available from the public stock centers) and 1 wild-type. Loss-of-function mutations have been isolated which affect the ectopic wing vein, the somatic clone wing, the ocellar triangle and 30 other listed tissues and are recessive lethal, recessive visible, recessive somatic clone cell non-autonomous tissue polarity, (with Df(3L)ri-XT1) lethal, (with fng80) lethal, (with fngM69) semi-viable, (with fng11) lethal, (with fng129) lethal, (with fng14) lethal, (with fng1) lethal, (with fng2) semi-viable, (with fng35UZ-1) semi-viable, (with fng3) lethal, (with fng52) semi-viable, (with fng5) lethal, (with fng7 to 8) lethal, (with fngL19) lethal, (with fngL73) lethal, (with fngL81) lethal and (with fngL83) lethal. fng is discussed in 197 references (excluding sequence accessions), dated between 1994 and 2004. These include at least 18 studies of mutant phenotypes, 13 studies of wild-type function and 9 molecular studies. Among findings on fng function, fng is required cell-autonomously in the somatic polar cells for follicle formation and also for polar cell fate.

FlyBase Gene Summary FBgn0003118 pnt pointed Drosophila melanogaster CG17077 CG17077 CG17077 D-ets-2 D-Ets-2 ETS2 0123/09 0608/07 0998/12 3520 DMPOINT1A POINT E(E2F)3D pointed-P1 pointed-P2 EY3-1 ptd EK3-2 pointedP2 PNTP1 PNTP2 Ets2 Ets58AB Ets94F ets94F l(3)07825 l(3)j1B7 Ets at 58AB 20 Aug 04 3R complement(19107483..19162541) AE003742 pnt-RB pnt-PB (718 aa) pnt-RD pnt-PD (636 aa) pnt-RC pnt-PC (623 aa) specific RNA polymerase II transcription factor activity inferred from sequence similarity with MGD:Ets1; MGI:MGI:95455 specific RNA polymerase II transcription factor activity MAPKKK cascade R7 development RAS protein signal transduction anti-apoptosis epidermal growth factor receptor signaling pathway heart development hemopoiesis heterophilic cell adhesion mesoderm development negative regulation of cardioblast cell fate specification ovarian follicle cell development (sensu Insecta) pericardial cell differentiation peripheral nervous system development regulation of transcription regulation of transcription from Pol II promoter secondary tracheal branching (sensu Insecta) terminal region determination torso signaling pathway tracheal system development (sensu Insecta) nucleus embryo VUM neuron interface glial cell embryonic/larval tracheal system mesoderm larva morphogenetic furrow IPR000418 == Ets-domain IPR002341 == HSF/ETS DNA-binding domain IPR003118 == Sterile &agr; motif (SAM)/Pointed domain SCOP:47769 == SAM/Pointed domain; pnt|FBgn0003118|pp-CT37466|FBan0017077 DEDB:10265 FlyGRID:FBgn0003118 IFly:../neural/pointed.htm KWgx:FBgn0003118 NCBI_GEO:FBgn0003118 FBrf0151249 Cripps and Olson 2002 Dev. Biol. 246(1): 14--28 Review FBrf0131240 Affolter and Shilo 2000 Curr. Opin. Cell Biol. 12(6): 731--735 Review FBrf0128450 Dobens and Raftery 2000 Dev. Dynamics 218(1): 80--93 Review FBrf0134816 Hsu and Schulz 2000 Oncogene 19(55): 6409--6416 Review FBrf0127283 Raabe 2000 Biochim. biophys. Acta 1496(2-3): 151--163 Review

The D. melanogaster gene pointed, abbreviated as pnt, is reported here. It has also been known in FlyBase as Ets58AB. It encodes a product with specific RNA polymerase II transcription factor activity involved in torso signaling pathway which is localized to the nucleus; it is expressed in the embryo (VUM neuron, embryonic/larval tracheal system, imaginal disc anlagen, interface glial cell and 6 other listed tissues) and larva (morphogenetic furrow and ommatidium). It has been sequenced and its amino acid sequence contains an ets-domain, a HSF/ETS DNA-binding domain and a sterile &agr; motif (SAM)/Pointed domain. It has been mapped by recombination to 3-79.0 and cytologically to 94E10--13. It interacts genetically with Ras85D, phl, Jra, Dsor1, pros and 18 other listed genes. There are 68 recorded alleles: 12 in vitro constructs (2 available from the public stock centers), 55 classical mutants (5 available from the public stock centers) and 1 wild-type. Amorphic mutations have been isolated which affect the trachea and the central nervous system and are recessive lethal. pnt is discussed in 277 references (excluding sequence accessions), dated between 1984 and 2004. These include at least 36 studies of mutant phenotypes, 3 studies of wild-type function and 10 molecular studies. Among findings on pnt mutants, pnt mutants display a pointed head skeleton and deletion of the medial portion in all denticle belts.

FlyBase Gene Summary FBgn0003870 ttk tramtrack Drosophila melanogaster CG11558 CG1856 CG11558 CG1856 CG1856 oss osn ttk/FTZ-F2 FTZ-F2 oversensitive Ttk E(yan)100D schmal 0037/17 0250/25 0438/31 0702/07 1049/07 1119/04 1184/16 1209/05 1209/10 1260/10 1281/04 1325/15 1372/08 1396/14 1418/06 3540 5125 5311 clone 2.9 Ttk69 ftzf2/ttk tramtrack69 TTK88 ttk69 ttkp69 Tramtrack69 anon-EST:Liang-2.9 ftz-f2 l(3)02667 l(3)j2A1 l(3)j7B8 ovs Enhancer of yan at 100D 20 Aug 04 3R 27528972..27550480 AE003779 ttk-RD ttk-PD (643 aa) ttk-RA ttk-PA (813 aa) ttk-RC ttk-PC (643 aa) ttk-RB ttk-PB (813 aa) ttk-RF ttk-PF (643 aa) ttk-RE ttk-PE (813 aa) specific RNA polymerase II transcription factor activity non-traceable author statement transcriptional repressor activity non-traceable author statement specific RNA polymerase II transcription factor activity transcriptional repressor activity R7 development cell fate determination chromatin assembly or disassembly dorsal appendage formation negative regulation of transcription from Pol II promoter peripheral nervous system development regulation of transcription from Pol II promoter sex determination transmission of nerve impulse nucleus polytene chromosome embryo ectoderm mesoderm anterior midgut primordium pole cell posterior midgut primordium stomodeum yolk nuclei tracheal pit IPR000210 == BTB/POZ domain IPR000637 == HMG-I and HMG-Y DNA-binding domain (A+T-hook) IPR000822 == Zinc finger, C2H2 type BDGPisx:ttk DEDB:11313 FlyGRID:FBgn0003870 Hybrigenics:521274 Hybrigenics:522209 IFly:../gene/tramtrac.htm KWgx:FBgn0003870 NCBI_GEO:FBgn0003870 FBrf0127283 Raabe 2000 Biochim. biophys. Acta 1496(2-3): 151--163 Review FBrf0111376 Granderath and Klambt 1999 Curr. Opin. Neurobiol. 9(5): 531--536 Review FBrf0100672 Dickson 1998 Curr. Biol. 8(3): R90--R92 Review FBrf0105975 Hawkins and Garriga 1998 Genes Dev. 12(23): 3625--3638 Review

The D. melanogaster gene tramtrack, abbreviated as ttk, is reported here. It has also been known in FlyBase as CG11558, CG1856 and ovs. It encodes a product with transcriptional repressor activity involved in R7 development which is localized to the nucleus; it is expressed in the embryo (anterior midgut primordium, ectoderm, mesoderm, pole cell and 5 other listed tissues) and prepupa and pupa (cone cell, photoreceptor cell, primary pigment cell, secondary pigment cell and 2 other listed tissues). It has been sequenced and its amino acid sequence contains a BTB/POZ domain, a HMG-I and HMG-Y DNA-binding domain (A+T-hook) and a zinc finger, C2H2 type. It has been mapped by recombination to 3-102.7 and cytologically to 100D1. It interacts genetically with aop, msi, CtBP, Gap1, Ras85D and 14 other listed genes. There are 106 recorded alleles: 46 in vitro constructs (4 available from the public stock centers), 59 classical mutants (3 available from the public stock centers) and 1 wild-type. Amorphic mutations have been isolated which affect the somatic clone ommatidium, the filzkorper, the mouth hooks and 14 other listed tissues and are embryonic lethal. ttk is discussed in 218 references (excluding sequence accessions), dated between 1986 and 2004. These include at least 27 studies of mutant phenotypes, 8 studies of wild-type function and 12 molecular studies. Among findings on ttk mutants, mutation in ttk affects the neuronal lineage, causes transformation of support cells into neurons. Among findings on ttk function, down-regulation of ttk protein expression occurs in photoreceptor cells and is required for their fate determination.

FlyBase Gene Summary FBgn0004635 rho rhomboid Drosophila melanogaster CG1004 CG1004 ve: veinlet Rho: Rhombotin DMRHOa DMRHOb Ve DRORHO DMRHO RHOb Rhomboid rhom RHO rho-1 veinlet Veinlet Rhomboid-1 rho1 rhomboid-1 Rho-1 rhomboid1 ve Rho rhomboid/veinlet 20 Aug 04 3L 1444421..1449112 AE003471 rho-RA rho-PA (355 aa) serine-type peptidase activity inferred from direct assay serine-type peptidase activity inferred from genetic interaction with FLYBASE:spi; FB:FBgn0005672 serine-type peptidase activity inferred from mutant phenotype serine-type peptidase activity inferred from sequence similarity serine-type peptidase activity traceable author statement receptor binding inferred from electronic annotation receptor signaling protein activity inferred from electronic annotation receptor binding receptor signaling protein activity serine-type peptidase activity brain development branch cell fate determination (sensu Insecta) branching morphogenesis ectoderm development epidermal growth factor ligand processing epidermal growth factor receptor signaling pathway leg disc proximal/distal pattern formation oenocyte development ovarian follicle cell development (sensu Insecta) peripheral nervous system development positive regulation of epidermal growth factor receptor signaling pathway proteolysis and peptidolysis regulation of epidermal growth factor receptor activity salivary gland determination salivary gland development tracheal system development (sensu Insecta) wing vein specification Golgi apparatus NOT endoplasmic reticulum NOT plasma membrane integral to membrane integral to plasma membrane plasma membrane embryo mesectoderm ventral midline tracheal pit chordotonal organ Malpighian tubule tip cell embryo stage >=12 central nervous system larva, pupa wing vein oogenesis, adult follicle cell pupa wing vein L1 DEDB:1942 FlyGRID:FBgn0004635 IFly:../torstoll/rhombid1.htm NCBI_GEO:FBgn0004635 FBrf0159337 Abrams et al. 2003 Trends Cell Biol. 13(5): 247--254 Review FBrf0158927 Shilo 2003 Exp. Cell Res. 284(1): 140--149 Review FBrf0159734 Urban 2003 Curr. Opin. Genet. Dev. 12(5): 512--518 Review FBrf0158727 de Celis 2003 BioEssays 25(5): 443--451 Review

The D. melanogaster gene rhomboid, abbreviated as rho, is reported here. It has also been known in FlyBase as MS:DRORHO and ve. It encodes a product with serine-type peptidase activity involved in peripheral nervous system development which is localized to the plasma membrane; it is expressed in the embryo (Malpighian tubule tip cell, chordotonal organ, mesectoderm, tracheal pit and 2 other listed tissues), larva (ommatidia, photoreceptor cell R2, photoreceptor cell R5, photoreceptor cell R8 and 2 other listed tissues), ovary (follicle cell) and prepupa and pupa (crossvein, wing vein and wing vein L1 to 5). It has been sequenced and its amino acid sequence is also available. It has been mapped by recombination to 3-0.2 and cytologically to 62A4. It interacts genetically with Egfr, bs, vn, dpp, S and 75 other listed genes. There are 58 recorded alleles: 29 in vitro constructs (none available from the public stock centers), 28 classical mutants (4 available from the public stock centers) and 1 wild-type. Amorphic mutations have been isolated which affect the embryonic ventral nervous system, the ventral denticle belt, the Keilin's organ and 19 other listed tissues and are embryonic recessive lethal. rho is discussed in 506 references (excluding sequence accessions), dated between 1919 and 2004. These include at least 71 studies of mutant phenotypes, 8 studies of wild-type function and 9 molecular studies. Among findings on rho mutants, rho mutants display a pointed head skeleton and deletion of the medial portion in all denticle belts. Among findings on rho function, the rho NEE enhancer element does not discriminate between TATA-containing and TATA-less promoters.

FlyBase Gene Summary FBgn0001308 Khc Kinesin heavy chain Drosophila melanogaster CG7765 CG7765 kinesin kin khc Dmkin KHC l(2)k13314 kinesin &agr; subunit DmKHC Kin: Kinesin DKH l(2R)W12 kinesin &agr;-chain l(2)W12 KIF5A KIN DK Kinesin Kin Khc 20 Aug 04 2R complement(11330690..11335703) AE003807 Khc-RA Khc-PA (975 aa) microtubule binding microtubule binding inferred from direct assay microtubule binding inferred from sequence similarity with EMBL:AF067180 microtubule motor activity non-traceable author statement motor activity non-traceable author statement structural constituent of cytoskeleton inferred from electronic annotation microtubule motor activity inferred from sequence similarity plus-end-directed microtubule motor activity ; ; EC:3.6.4.4 traceable author statement microtubule motor activity inferred from sequence similarity with EMBL:AF067180 structural constituent of cytoskeleton motor activity microtubule motor activity plus-end-directed microtubule motor activity ; ; EC:3.6.4.4 action potential propagation cytoplasmic transport, nurse cell to oocyte microtubule-based movement neurotransmitter secretion oocyte dorsal/ventral axis determination pole plasm assembly pole plasm oskar mRNA localization protein targeting regulation of pole plasm oskar mRNA localization kinesin complex adult head larva photoreceptor cell IPR001752 == Kinesin motor domain SCOP:52540 == P-loop containing nucleotide triphosphate hydrolases; Khc|FBgn0001308|pp-CT23616|FBan0007765 DEDB:12093 FlyGRID:FBgn0001308 Hybrigenics:521616 KWgx:FBgn0001308 NCBI_GEO:FBgn0001308 FBrf0155474 Cohen 2002 Curr. Biol. 12(23): R797--R799 Review FBrf0144782 Palacios 2002 Curr. Biol. 12(2): R50--R52 Review FBrf0155512 Pellettieri and Seydoux 2002 Science 298(5600): 1946--1950 Review FBrf0156097 Tekotte and Davis 2002 Trends Genet. 18(12): 636--642 Review

The D. melanogaster gene Kinesin heavy chain, abbreviated as Khc, is reported here. It has also been known in FlyBase as l(2)W12 and l(2)k13314. It encodes a product with motor activity involved in regulation of pole plasm oskar mRNA localization which is localized to the cytoplasm; it is expressed in the adult (head). It has been sequenced and its amino acid sequence contains a kinesin motor domain. It has been mapped cytologically to 53A2--3. It interacts genetically with E(Khc)ek4, Dhc64C, Sh, eag, mle and 7 other listed genes. There are 48 recorded alleles: 6 in vitro constructs (none available from the public stock centers), 41 classical mutants (2 available from the public stock centers) and 1 wild-type. Amorphic mutations have been isolated which affect the somatic clone eye, the somatic clone ommatidium, the somatic clone photoreceptor cell and 4 other listed tissues and are recessive lethal and recessive somatic clone visible. Khc is discussed in 262 references (excluding sequence accessions), dated between 1988 and 2004. These include at least 27 studies of mutant phenotypes, 6 studies of wild-type function and 11 molecular studies. Among findings on Khc mutants, Khc mutations cause axonal swellings that are filled with the cargoes of fast axonal transport, including many membrane-bounded organelles and synaptic membrane proteins. Among findings on Khc function, posterior localization of Dynein and dorsal-ventral axis formation in the oocyte is dependent on Khc.

FlyBase Gene Summary FBgn0000462 dl dorsal Drosophila melanogaster CG6667 CG6667 CG6667 fs(2)k10816 dL mat(2)dorsal anon-EST:GressD7 20 Aug 04 2L complement(17414916..17428443) AE003655 dl-RC dl-PC (999 aa) dl-RB dl-PB (677 aa) dl-RA dl-PA (677 aa) DNA binding DNA binding non-traceable author statement transcription factor activity non-traceable author statement transcriptional activator activity traceable author statement RNA polymerase II transcription factor activity traceable author statement morphogen activity non-traceable author statement specific RNA polymerase II transcription factor activity inferred from sequence similarity with MGD:Rel; MGI:MGI:97897 transcriptional repressor activity traceable author statement RNA polymerase II transcription factor activity transcription factor activity specific RNA polymerase II transcription factor activity morphogen activity transcriptional activator activity transcriptional repressor activity I-kappaB kinase/NF-kappaB cascade Toll signaling pathway anterior/posterior pattern formation anti-apoptosis cellular defense response defense response dorsal/ventral axis specification dorsal/ventral pattern formation ectoderm cell fate specification ectoderm development gastrulation germ cell migration heart development immune response maternal determination of anterior/posterior axis, embryo mesoderm cell fate specification mesoderm development negative regulation of transcription negative regulation of transcription from Pol II promoter negative regulation of transcription, DNA-dependent positive regulation of transcription from Pol II promoter positive regulation of transcription, DNA-dependent regulation of transcription ventral cord development cytoplasm nucleus embryo ovary larval fat body IPR000451 == NF-&kgr;-B/Rel/dorsal family SCOP:48726 == Immunoglobulin; dl|FBgn0000462|pp-CT20676|FBan0006667 SCOP:48726 == Immunoglobulin; dl|FBgn0000462|pp-CT20694|FBan0006667 SCOP:48726 == Immunoglobulin; dl|FBgn0000462|pp-CT42418|FBan0006667 SCOP:49417 == p53-like transcription factors; dl|FBgn0000462|pp-CT20676|FBan0006667 SCOP:49417 == p53-like transcription factors; dl|FBgn0000462|pp-CT20694|FBan0006667 SCOP:49417 == p53-like transcription factors; dl|FBgn0000462|pp-CT42418|FBan0006667 DEDB:7871 FlyGRID:FBgn0000462 Hybrigenics:521795 IFly:../torstoll/dorsal1.htm KWgx:FBgn0000462 NCBI_GEO:FBgn0000462 FBrf0155688 Silverman 2003 Dev. Cell 4(1): 5--6 Review FBrf0151249 Cripps and Olson 2002 Dev. Biol. 246(1): 14--28 Review FBrf0159908 Janssens and Beyaert 2002 Trends Biochem. Sci. 27(9): 474--482 Review FBrf0149180 Khush et al. 2002 Science 296: 273--275 Review FBrf0148941 Stathopoulos and Levine 2002 Dev. Biol. 246(1): 57--67 Review

The D. melanogaster gene dorsal, abbreviated as dl, is reported here. It has also been known in FlyBase as anon-EST:GreesD7, anon-EST:GressD7 and anon-ESTGreesD7. It encodes a product with DNA binding involved in maternal determination of anterior/posterior axis, embryo which is localized to the cytoplasm and the nucleus; it is expressed in the adult (ovary and ovary), embryo (mesoderm and ventral furrow), larva (larval fat body) and ovary (nurse cell). It has been sequenced and its amino acid sequence contains a NF-&kgr;-B/Rel/dorsal family. It has been mapped by recombination to 2-52.9 and cytologically to 36C8--9. It interacts genetically with cact, RpII140, fs(1)Yb, fog, Dif and 4 other listed genes. There are 111 recorded alleles: 64 in vitro constructs (none available from the public stock centers), 46 classical mutants (4 available from the public stock centers) and 1 wild-type. Amorphic mutations have been isolated which affect the ventral embryonic/first instar larval cuticle, the adult salivary gland primordium, the endoderm and 5 other listed tissues and are maternal effect recessive lethal. dl is discussed in 516 references (excluding sequence accessions), dated between 1979 and 2004. These include at least 66 studies of mutant phenotypes, 10 studies of wild-type function, one study of natural polymorphisms and 24 molecular studies. Among findings on dl mutants, mutations in dl result in a maternal effect phenotype with defects during the early stages of gastrulation and defects in the dorsoventral axis; embryos derived from homozygous females are dorsalized.

FlyBase Gene Summary FBgn0000382 csw corkscrew Drosophila melanogaster CG3954 CG3954 CG3954 CG3954 l(1)csw l(1)2Db E(sev)1A: Enhancer of sevenless 1A 19-106 l(1)2Dd Csw l(1)G0170 CSW Csw/Shp2 EG:BACN25G24.2 l(1)GA114 E(sev)1A Enhancer of sevenless 1A 20 Aug 04 X 1851008..1870437 AE003423 csw-RA csw-PA (841 aa) csw-RC csw-PC (682 aa) csw-RB csw-PB (945 aa) protein tyrosine phosphatase activity ; ; EC:3.1.3.48 non-traceable author statement protein tyrosine phosphatase activity ; ; EC:3.1.3.48 inferred from direct assay non-membrane spanning protein tyrosine phosphatase activity non-traceable author statement non-membrane spanning protein tyrosine phosphatase activity inferred from sequence similarity receptor signaling protein tyrosine phosphatase activity non-traceable author statement protein tyrosine phosphatase activity ; ; EC:3.1.3.48 non-membrane spanning protein tyrosine phosphatase activity receptor signaling protein tyrosine phosphatase activity R7 cell fate commitment determination of anterior/posterior axis, embryo dorsal/ventral axis determination, follicular epithelium (sensu Insecta) epidermal growth factor receptor signaling pathway fibroblast growth factor receptor signaling pathway imaginal disc development mesoderm development primary tracheal branching (sensu Insecta) protein amino acid dephosphorylation sevenless signaling pathway terminal region determination torso signaling pathway tracheal cell migration (sensu Insecta) ventral midline development cytoplasm IPR000242 == Tyrosine specific protein phosphatase IPR000387 == Tyrosine specific protein phosphatase and dual specificity protein phosphatase family IPR000980 == Src homology 2 (SH2) domain SCOP:52799 == (Phosphotyrosine protein) phosphatases II; csw|FBgn0000382|pp-CT13063|FBan0003954 SCOP:52799 == (Phosphotyrosine protein) phosphatases II; csw|FBgn0000382|pp-CT37554|FBan0003954 SCOP:52799 == (Phosphotyrosine protein) phosphatases II; csw|FBgn0000382|pp-CT43319|FBan0003954 SCOP:55550 == SH2 domain; csw|FBgn0000382|pp-CT13063|FBan0003954 SCOP:55550 == SH2 domain; csw|FBgn0000382|pp-CT37554|FBan0003954 SCOP:55550 == SH2 domain; csw|FBgn0000382|pp-CT43319|FBan0003954 DEDB:307 FlyGRID:FBgn0000382 IFly:../torstoll/corkscr1.htm NCBI_GEO:FBgn0000382 FBrf0127283 Raabe 2000 Biochim. biophys. Acta 1496(2-3): 151--163 Review FBrf0111327 Baek and Lee 1999 J. Biomed. Sci. 6(5): 314--319 Review FBrf0124979 Feng 1999 Exp. Cell Res. 253(1): 47--54 Review FBrf0109590 den Hertog 1999 Mech. Dev. 85(1,2): 3--14 Review

The D. melanogaster gene corkscrew, abbreviated as csw, is reported here. It has also been known in FlyBase as CG3954 and l(1)G0170. It encodes a product with protein tyrosine phosphatase activity (EC:3.1.3.48) involved in epidermal growth factor receptor signaling pathway which is a component of the cytoplasm. It has been sequenced and its amino acid sequence contains a tyrosine specific protein phosphatase, a tyrosine specific protein phosphatase and dual specificity protein phosphatase family and a src homology 2 (SH2) domain. It has been mapped by recombination to 1-1 and cytologically to 2D1--2. It interacts genetically with dos, svp, Ras85D, Src42A, Egfr and 20 other listed genes. There are 44 recorded alleles: 19 in vitro constructs (none available from the public stock centers), 24 classical mutants (1 available from the public stock centers) and 1 wild-type. Amorphic mutations have been isolated which affect the germ-line clone embryonic/first instar larval cuticle and are pupal lethal. csw is discussed in 132 references (excluding sequence accessions), dated between 1983 and 2004. These include at least 23 studies of mutant phenotypes, 3 studies of wild-type function and 8 molecular studies. Among findings on csw function, csw has a positive role in embryonic mesoderm development.

FlyBase Gene Summary FBgn0028734 Fmr1 Drosophila melanogaster CG6203 CG6203 FXR Fragile-X-related cg6203 dFMR1 dfmr1 dFXR FMR1 dfxr dFmr1 fragile X AT24755 EP(3)3517 dmfr1 dFXR1 dFMRP dfxr1 fmr Fragile X-related dfmr BcDNA:GM08679 Fragile X related 20 Aug 04 3R complement(5927154..5935862) AE003685 Fmr1-RE Fmr1-PE (643 aa) Fmr1-RD Fmr1-PD (681 aa) Fmr1-RC Fmr1-PC (681 aa) Fmr1-RA Fmr1-PA (684 aa) Fmr1-RB Fmr1-PB (529 aa) RNA binding mRNA binding mRNA binding non-traceable author statement mRNA binding inferred from direct assay protein binding inferred from physical interaction with FLYBASE:AGO2; FB:FBgn0046812 protein binding inferred from physical interaction with FLYBASE:Rm62; FB:FBgn0003261 protein binding inferred from physical interaction with FLYBASE:RpL11; FB:FBgn0013325 protein binding inferred from physical interaction with FLYBASE:RpL5; FB:FBgn0064225 protein binding RNA binding inferred from sequence similarity with UniProt:P51116 NOT chemotaxis NOT phototaxis NOT synaptic transmission axon guidance circadian rhythm induction of apoptosis locomotion locomotor rhythm male courtship behavior (sensu Insecta) negative regulation of translation neurotransmitter secretion nucleobase, nucleoside, nucleotide and nucleic acid metabolism nucleobase, nucleoside, nucleotide and nucleic acid transport regulation of dendrite morphogenesis regulation of synapse structure regulation of synaptic growth at neuromuscular junction regulation of translation sperm axoneme assembly synaptogenesis RNA-induced silencing complex cytoplasm micro-ribonucleoprotein complex IPR000958 == KH domain IPR003029 == S1 RNA binding domain SCOP:54791 == KH-domain; Fmr1|FBgn0028734|pp-CT17036|FBan0006203 DEDB:8728 FlyGRID:FBgn0028734 KWgx:FBgn0028734 NCBI_GEO:FBgn0028734 FBrf0157326 Driscoll and Gerstbrein 2003 Nature Rev. Genet. 4(3): 181--194 Review FBrf0159907 Jin and Warren 2003 Trends Biochem. Sci. 28(3): 152--158 Review FBrf0158807 Carthew 2002 Curr. Biol. 12(24): R852--R854 Review FBrf0149141 Gao 2002 Neuron 34(6): 859--862 Review FBrf0156127 Oostra 2002 Trends Mol. Med. 8(3): 102--103 Review

The D. melanogaster gene Fmr1 is reported here. It has also been known in FlyBase as BcDNA:GM08679, CG6203 and Fragile-X-related. It encodes a product with mRNA binding involved in negative regulation of translation which is a component of the RNA-induced silencing complex. It has been sequenced. It has been mapped cytologically to 85F10--12. It interacts genetically with th, futsch, Abl, pnr and Rac1. There are 35 recorded alleles: 18 in vitro constructs (1 available from the public stock centers), 16 classical mutants (4 available from the public stock centers) and 1 wild-type. Loss-of-function mutations have been isolated which affect the ventral adult lateral neuron, the dorsal cluster neuron, the (with Fmr1EP3517) ventral adult lateral neuron and 2 other listed tissues and are viable, recessive neuroanatomy defective, (with Fmr1&Dgr;83M) neuroanatomy defective, (with Fmr1&Dgr;50M) neuroanatomy defective, (with Fmr1EP3517) neuroanatomy defective, pharate adult partially lethal, recessive locomotor rhythm defective and recessive eclosion rhythm defective. Fmr1 is discussed in 60 references (excluding sequence accessions), dated between 1999 and 2004. These include at least 7 studies of mutant phenotypes, 4 studies of wild-type function and 7 molecular studies. Among findings on Fmr1 mutants, Fmr1 mutants show strong eclosion failure and circadian rhythm defects. Among findings on Fmr1 function, Fmr1 has a role in dendritic development.

FlyBase Gene Summary FBgn0000212 brm brahma Drosophila melanogaster CG18438 CG5942 CG18438 l(3)72Aa Brm BRM E(E2F)3A dBRM 20 Aug 04 3L complement(15918961..15931748) AE003529 brm-RC brm-PC (1634 aa) brm-RD brm-PD (1634 aa) brm-RB brm-PB (1638 aa) brm-RA brm-PA (1638 aa) nucleic acid binding general RNA polymerase II transcription factor activity inferred from sequence similarity with SGD_LOCUS:SNF2; SGD:S0005816 nucleic acid binding inferred from electronic annotation transcription coactivator activity non-traceable author statement DNA helicase activity inferred from electronic annotation transcription coactivator activity inferred from sequence similarity with SGD_LOCUS:SNF2; SGD:S0005816 transcription coactivator activity general RNA polymerase II transcription factor activity DNA helicase activity DNA-dependent ATPase activity DNA-dependent ATPase activity non-traceable author statement chromatin-mediated maintenance of transcription hemocyte proliferation (sensu Arthropoda) oogenesis (sensu Insecta) regulation of transcription from Pol II promoter wing vein specification brahma complex nucleosome remodeling complex nucleus embryo-pupa unfertilized egg IPR000330 == SNF2 related domain IPR001410 == DEAD/DEAH box helicase IPR001650 == Helicase C-terminal domain DEDB:3941 FlyGRID:FBgn0000212 IFly:../polycomb/brahma.htm KWgx:FBgn0000212 NCBI_GEO:FBgn0000212 FBrf0151521 Klochendler-Yeivin et al. 2002 Curr. Opin. Genet. Dev. 12(1): 73--79 Review FBrf0155574 Neely and Workman 2002 Biochim. biophys. Acta 1603(1): 19--29 Review FBrf0151518 Simon and Tamkun 2002 Curr. Opin. Genet. Dev. 12(2): 210--218 Review

The D. melanogaster gene brahma, abbreviated as brm, is reported here. It has also been known in FlyBase as CG18438. It encodes a product with general RNA polymerase II transcription factor activity involved in chromatin-mediated maintenance of transcription which is a component of the nucleus; it is expressed in the unfertilized egg). It has been sequenced and its amino acid sequence contains a SNF2 related domain, a DEAD/DEAH box helicase and a helicase C-terminal domain. It has been mapped by recombination to 3-43.0 and cytologically to 72C1. It interacts genetically with trx, Antp, Snr1, Psc, osa and 34 other listed genes. There are 39 recorded alleles: 7 in vitro constructs (none available from the public stock centers), 31 classical mutants (2 available from the public stock centers) and 1 wild-type. Amorphic mutations have been isolated which affect the abdominal segment 6, the larval hemocyte and the wing and are recessive lethal and recessive somatic clone visible. brm is discussed in 174 references (excluding sequence accessions), dated between 1988 and 2004. These include at least 31 studies of mutant phenotypes, 9 studies of wild-type function and 13 molecular studies. Among findings on brm function, the chromatin remodelling activity of the brm complex may play a general role in facilitating transcription by RNA polymerase II.

FlyBase Gene Summary FBgn0003447 sn singed Drosophila melanogaster CG1536 CG32858 CG15331 CG1536 fs(1)M45 fs(1)K418 fascin Sn fs(1)A1057 fs(1)K1421 fs(1)K473 fs(1)K743 20 Aug 04 X 7702970..7725047 AE003442 sn-RB sn-PB (512 aa) sn-RC sn-PC (564 aa) sn-RA sn-PA (512 aa) actin binding actin binding inferred from sequence similarity structural constituent of cytoskeleton inferred from electronic annotation structural constituent of cytoskeleton actin filament bundle formation actin filament organization bristle morphogenesis cell cycle cytoskeleton organization and biogenesis female gamete generation oogenesis (sensu Insecta) visual perception oogenesis ovary oogenesis, adult ovary SCOP:50405 == Actin-crosslinking proteins; sn|FBgn0003447|pp-CT3977|FBan0001536 DEDB:785 FlyGRID:FBgn0003447 IFly:../newgene/singed.htm KWgx:FBgn0003447 NCBI_GEO:FBgn0003447 FBrf0151730 Hudson and Cooley 2002 A. Rev. Genet. 36: 455--488 Review FBrf0132269 Buszczak and Cooley 2000 Cell Death Diffn 7(11): 1071--1074 Review FBrf0102160 Ayscough 1998 Curr. Opin. Cell Biol. 10(1): 102--111 Review

The D. melanogaster gene singed, abbreviated as sn, is reported here. It has also been known in FlyBase as CG15331. It encodes a product with putative actin binding involved in actin filament bundle formation which is localized to the cytoplasm; it is expressed in the ovary (ovary, border follicle cell, oocyte and ovary) and prepupa and pupa (macrochaetae and socket). It has been sequenced and its amino acid sequence is also available. It has been mapped by recombination to 1-21.0 and cytologically to 7D1--2. It interacts genetically with qua. There are 195 recorded alleles: 191 classical mutants (13 available from the public stock centers) and 4 wild-type. Amorphic mutations have been isolated which affect the macrochaeta, the egg and the egg chamber and are recessive sterile. sn is discussed in 233 references (excluding sequence accessions), dated between 1922 and 2004. These include at least 9 studies of mutant phenotypes, one study of natural polymorphisms and 3 molecular studies. Among findings on sn mutants, mutations in sn induced by P-M hybrid dysgenesis have been analyzed to determine why sn is a hotspot for mutation during P-M hybrid dysgenesis.

FlyBase Gene Summary FBgn0003317 sax saxophone Drosophila melanogaster CG1891 CG1891 Sax Brk43E Bkr43E STK-B 20 Aug 04 2R 2867379..2870971 AE003839 sax-RB sax-PB (535 aa) sax-RA sax-PA (570 aa) protein serine/threonine kinase activity non-traceable author statement protein kinase activity ; ; EC:2.7.1.37 non-traceable author statement type I transforming growth factor beta receptor activity non-traceable author statement hematopoietin/interferon-class (D200-domain) cytokine receptor activity inferred from electronic annotation type I transforming growth factor beta receptor activity inferred from direct assay protein serine/threonine kinase activity protein kinase activity ; ; EC:2.7.1.37 type I transforming growth factor beta receptor activity hematopoietin/interferon-class (D200-domain) cytokine receptor activity BMP signaling pathway anterior/posterior pattern formation, imaginal disc compound eye morphogenesis (sensu Drosophila) cytokine and chemokine mediated signaling pathway maternal determination of anterior/posterior axis, embryo mesoderm development nurse cell to ocyte transport (sensu Insecta) oogenesis (sensu Insecta) ovarian follicle cell development (sensu Insecta) positive regulation of synaptic growth at neuromuscular junction protein amino acid phosphorylation transforming growth factor beta receptor signaling pathway wing morphogenesis plasma membrane IPR000472 == TGF-&bgr; receptor family, extracellular domain/Activin types I and II receptor domain IPR000719 == Eukaryotic protein kinase IPR002290 == Serine/Threonine protein kinase family active site IPR003605 == GS motif preceding kinase domain in TGF &bgr; receptor SCOP:56112 == Protein kinase-like (PK-like); sax|FBgn0003317|pp-CT5838|FBan0001891 SCOP:57302 == Snake toxin-like; sax|FBgn0003317|pp-CT5838|FBan0001891 DEDB:13265 FlyGRID:FBgn0003317 IFly:../gene/saxophon.htm KWgx:FBgn0003317 NCBI_GEO:FBgn0003317 FBrf0141762 Baker 2001 Semin. Cell Dev. Biol. 12(6): 499--507 Review FBrf0132269 Buszczak and Cooley 2000 Cell Death Diffn 7(11): 1071--1074 Review FBrf0128450 Dobens and Raftery 2000 Dev. Dynamics 218(1): 80--93 Review FBrf0130228 Nakayama et al. 2000 Cell. Molec. Life Sci. 57(6): 943--956 Review FBrf0131044 Zimmerman and Padgett 2000 Gene 249(1-2): 17--30 Review

The D. melanogaster gene saxophone, abbreviated as sax, is reported here. It encodes a product with type I transforming growth factor beta receptor activity involved in maternal determination of anterior/posterior axis, embryo which is a component of the plasma membrane. It has been sequenced and its amino acid sequence contains a TGF-&bgr; receptor family, extracellular domain/Activin types I and II receptor domain, an eukaryotic protein kinase, a serine/Threonine protein kinase family active site and a GS motif preceding kinase domain in TGF &bgr; receptor. It has been mapped by recombination to 2-57 and cytologically to 43E18. It interacts genetically with tkv, Mad, dpp, scw, Med and 10 other listed genes. There are 34 recorded alleles: 19 in vitro constructs (none available from the public stock centers), 14 classical mutants (2 available from the public stock centers) and 1 wild-type. Amorphic mutations have been isolated which affect the germ-line clone ovary, the germ-line clone egg, the germ-line clone dorsal appendage and 11 other listed tissues and are recessive lethal, recessive somatic clone visible, (with Df(2R)cn7969) neuroanatomy defective, (with Df(2R)sax-H9) neuroanatomy defective and (with sax5) neurophysiology defective. sax is discussed in 153 references (excluding sequence accessions), dated between 1989 and 2004. These include at least 18 studies of mutant phenotypes, 4 studies of wild-type function and 8 molecular studies. Among findings on sax mutants, mutations in sax result in a maternal effect phenotype with defects during the early stages of gastrulation. Among findings on sax function, sax protein participates in the determination of the anterior posterior margin fate in the developing wing pouch, even at the extreme anterior edge.

FlyBase Gene Summary FBgn0005386 ash1 absent, small, or homeotic discs 1 Drosophila melanogaster CG8887 CG8887 dash: discs absent, small, or homeotic ash-1 ASH1 ash Ash1 l(3)SG29a discs absent, small, or homeotic 20 Aug 04 3L complement(19541259..19548705) AE003516 ash1-RA ash1-PA (2217 aa) histone methyltransferase activity inferred from direct assay histone lysine N-methyltransferase activity (H4-K20 specific) non-traceable author statement histone methyltransferase activity inferred from sequence similarity with SGD_LOCUS:SET1; SGD:S0001161 histone lysine N-methyltransferase activity (H3-K4 specific) non-traceable author statement histone lysine N-methyltransferase activity (H3-K9 specific) non-traceable author statement transcription regulator activity inferred from electronic annotation histone lysine N-methyltransferase activity (H3-K4 specific) traceable author statement histone lysine N-methyltransferase activity (H4-K20 specific) traceable author statement histone lysine N-methyltransferase activity (H3-K4 specific) inferred from direct assay histone lysine N-methyltransferase activity (H3-K4 specific) inferred from mutant phenotype histone lysine N-methyltransferase activity (H3-K9 specific) traceable author statement transcription regulator activity histone lysine N-methyltransferase activity (H3-K4 specific) histone methyltransferase activity histone lysine N-methyltransferase activity (H4-K20 specific) histone lysine N-methyltransferase activity (H3-K9 specific) chromatin-mediated maintenance of transcription embryonic development (sensu Insecta) histone methylation oogenesis (sensu Insecta) oviposition regulation of transcription from Pol II promoter nucleus embryo imaginal disc oogenesis, adult nurse cell IPR001025 == BAH (bromo-adjacent homology) domain IPR001965 == PHD-finger DEDB:3536 FlyGRID:FBgn0005386 KWgx:FBgn0005386 NCBI_GEO:FBgn0005386 FBrf0159912 Marmorstein 2003 Trends Biochem. Sci. 28(2): 59--62 Review FBrf0102337 Jan and Jan 1998 Nature 392(6678): 775--778 Review FBrf0100732 Jenuwein et al. 1998 Cell. Molec. Life Sci. 54(1): 80--83 Review

The D. melanogaster gene absent, small, or homeotic discs 1, abbreviated as ash1, is reported here. It encodes a product with histone lysine N-methyltransferase activity (H3-K4 specific) involved in oogenesis (sensu Insecta) which is a component of the nucleus; it is expressed in the larva (imaginal disc) and ovary (nurse cell). It has been sequenced and its amino acid sequence contains a BAH (bromo-adjacent homology) domain and a PHD-finger. It has been mapped by recombination to 3-46.6 and cytologically to 76B8--9. It interacts genetically with E(z), brm, trx, fs(1)h, Scr and 27 other listed genes. There are 39 recorded alleles: 5 in vitro constructs (none available from the public stock centers), 33 classical mutants (1 available from the public stock centers) and 1 wild-type. Hypomorphic mutations have been isolated which affect the wing and are pharate adult recessive lethal and homeotic visible. ash1 is discussed in 81 references (excluding sequence accessions), dated between 1971 and 2004. These include at least 18 studies of mutant phenotypes, 2 studies of wild-type function and 5 molecular studies. Among findings on ash1 mutants, ash1 mutant larvae may have small or absent imaginal discs or express homeotic transformations. Among findings on ash1 function, ash1 is one of the trithorax group of genes.

FlyBase Gene Summary FBgn0003742 tra2 transformer 2 Drosophila melanogaster CG10128 tra-2 Tra2 TRA-2 transformer-2 20 Aug 04 2R complement(9665730..9668078) AE003814 tra2-RG tra2-PG (264 aa) tra2-RF tra2-PF (264 aa) tra2-RC tra2-PC (226 aa) tra2-RB tra2-PB (136 aa) tra2-RA tra2-PA (264 aa) tra2-RE tra2-PE (179 aa) tra2-RD tra2-PD (226 aa) RNA binding RNA binding inferred from sequence similarity RNA binding non-traceable author statement pre-mRNA splicing factor activity inferred from electronic annotation pre-mRNA splicing factor activity RNA splicing female sex determination female somatic sex determination mRNA processing male somatic sex determination regulation of nuclear mRNA splicing, via spliceosome reproduction sex determination spermatogenesis spliceosome assembly adult ovary testis germline IPR000504 == RNA-binding region RNP-1 (RNA recognition motif) SCOP:54928 == RNA-binding domain, RBD; tra2|FBgn0003742|pp-CT28507|FBan0010128 DEDB:12319 FlyGRID:FBgn0003742 IFly:../dbzhnsky/transf21.htm KWgx:FBgn0003742 NCBI_GEO:FBgn0003742 FBrf0159373 Emmons and Lipton 2003 J. Neurobiol. 54(1): 93--110 Review FBrf0150778 Maniatis 2002 Nature 418(6894): 236--243 Review FBrf0135681 Baker et al. 2001 Cell 105(1): 13--24 Review

The D. melanogaster gene transformer 2, abbreviated as tra2, is reported here. It encodes a product with RNA binding involved in mRNA processing which is expressed in the adult (germline and testis). It has been sequenced and its amino acid sequence contains a RNA-binding region RNP-1 (RNA recognition motif). It has been mapped by recombination to 2-70 and cytologically to 51B6. It interacts genetically with dsx, B52 and Doa. There are 63 recorded alleles: 45 in vitro constructs (none available from the public stock centers), 17 classical mutants (2 available from the public stock centers) and 1 wild-type. Amorphic mutations have been isolated which affect the germ cell, the sex comb, the female reproductive system and 4 other listed tissues and are recessive sex-determination defective, recessive female sterile, recessive male sterile and (with Df(2R)trix) sex-determination defective. tra2 is discussed in 202 references (excluding sequence accessions), dated between 1975 and 2004. These include at least 27 studies of mutant phenotypes, 2 studies of wild-type function and 11 molecular studies.

FlyBase Gene Summary FBgn0003015 osk oskar Drosophila melanogaster CG10901 oskar 20 Aug 04 3R 4760868..4764138 AE003681 osk-RC osk-PC (468 aa) osk-RB osk-PB (606 aa) osk-RA osk-PA (606 aa) determination of anterior/posterior axis, embryo long-term memory maintenance of pole plasm mRNA localization (sensu Insecta) oocyte anterior/posterior axis determination polar granule organization and biogenesis pole cell development pole cell fate determination pole cell formation pole plasm assembly (sensu Insecta) pole plasm assembly pole plasm mRNA localization pole plasm protein localization (sensu Insecta) pole plasm protein localization positive regulation of translation regulation of oskar mRNA translation polar granule pole plasm oogenesis oocyte oogenesis, adult oocyte nurse cell germarium region 2b SCOP:52266 == Esterase/acetylhydrolase; osk|FBgn0003015|pp-CT30527|FBan0010901 SCOP:52266 == Esterase/acetylhydrolase; osk|FBgn0003015|pp-CT41904|FBan0010901 BDGPisx:osk DEDB:8560 FlyGRID:FBgn0003015 IFly:../torstoll/oskar1.htm NCBI_GEO:FBgn0003015 FBrf0157336 Leatherman and Jongens 2003 BioEssays 25(4): 326--335 Review FBrf0151858 Benton and St. Johnston 2002 Curr. Biol. 12(14): R479--R481 Review FBrf0159816 Bullock and Ish-Horowicz 2002 Nature Cell Biol. 4(5): E117--E118 Review FBrf0152348 Dean et al. 2002 Trends Genet. 18(11): 572--577 Review FBrf0156076 Kaltschmidt and Martinez Arias 2002 Trends Cell Biol. 12(7): 316--320 Review FBrf0144782 Palacios 2002 Curr. Biol. 12(2): R50--R52 Review FBrf0155512 Pellettieri and Seydoux 2002 Science 298(5600): 1946--1950 Review FBrf0150772 Schwarz and Zamore 2002 Genes Dev. 16(9): 1025--1031 Review FBrf0156097 Tekotte and Davis 2002 Trends Genet. 18(12): 636--642 Review

The D. melanogaster gene oskar, abbreviated as osk, is reported here. It encodes a product involved in pole plasm protein localization which is a component of the polar granule; it is expressed in the ovary (oocyte, egg chamber, germarium region 2b, nurse cell and 2 other listed tissues) and pole granule). It has been sequenced and its amino acid sequence is also available. It has been mapped by recombination to 3-48.4 and cytologically to 85B7. It interacts genetically with nos, aub, vas, Su(osk)2 to 3-O26, Su(osk)B11 and 26 other listed genes. There are 91 recorded alleles: 61 in vitro constructs (none available from the public stock centers), 29 classical mutants (1 available from the public stock centers) and 1 wild-type. Amorphic mutations have been isolated which affect the germ cell and the pole cell and are maternal effect recessive lethal. osk is discussed in 513 references (excluding sequence accessions), dated between 1986 and 2004. These include at least 37 studies of mutant phenotypes, 4 studies of wild-type function and 15 molecular studies. Among findings on osk mutants, studies of fluorescently labelled osk RNA injected into wild type or mutant embryos reveal that microtubule-dependent cytoplasmic flows could contribute to the long range transport of osk RNA, whereas microtubule independent processes could mediate short-range transport. Among findings on osk function, osk has a role in long-term memory.

FlyBase Gene Summary FBgn0003659 Sxl Sex lethal Drosophila melanogaster CG18350 fs(1)M106 Sxl-1 Sxl-2 Sx1 Sex-lethal sxl DmSxl sex-lethal Fl: Female lethal Mex156 Su(da) fs(1)K1274 l(1)6Fa Female lethal 20 Aug 04 RNA binding poly-pyrimidine tract binding RNA binding inferred from sequence similarity RNA binding traceable author statement pre-mRNA splicing factor activity non-traceable author statement translation repressor activity, nucleic acid binding traceable author statement poly-pyrimidine tract binding inferred from direct assay pre-mRNA splicing factor activity translation repressor activity, nucleic acid binding mRNA 5'-UTR binding mRNA 5'-UTR binding traceable author statement alternative nuclear mRNA splicing, via spliceosome dosage compensation female germ-line sex determination female sex determination female sex differentiation female somatic sex determination germ cell development meiotic recombination negative regulation of nuclear mRNA splicing via U2-type spliceosome negative regulation of nuclear mRNA splicing, via spliceosome negative regulation of translation nuclear mRNA splicing, via spliceosome oogenesis (sensu Insecta) regulation of nuclear mRNA splicing, via spliceosome sex determination sex determination, female germ-line determination sex determination, primary response to X:A ratio sex differentiation somatic sex determination spliceosome complex IPR000504 == RNA-binding region RNP-1 (RNA recognition motif) IPR002343 == Paraneoplastic encephalomyelitis antigen SCOP:54928 == RNA-binding domain, RBD; Sxl|FBgn0003659|pp-CT40521|FBan0018350 SCOP:54928 == RNA-binding domain, RBD; Sxl|FBgn0003659|pp-CT43415|FBan0018350 FlyGRID:FBgn0003659 IFly:../gene/sexlthl1.htm KWgx:FBgn0003659 NCBI_GEO:FBgn0003659 FBrf0157329 Charlat et al. 2003 Trends Genet. 19(4): 217--223 Review FBrf0157332 Stothard and Pilgrim 2003 BioEssays 25(3): 221--231 Review FBrf0152334 Burtis 2002 Science 297(5584): 1135--1136 Review FBrf0156093 Christiansen et al. 2002 Trends Genet. 18(10): 510--516 Review FBrf0152348 Dean et al. 2002 Trends Genet. 18(11): 572--577 Review FBrf0148923 Graveley 2002 Cell 109(4): 409--412 Review FBrf0150778 Maniatis 2002 Nature 418(6894): 236--243 Review

The D. melanogaster gene Sex lethal, abbreviated as Sxl, is reported here. It has also been known in FlyBase as CG18350. It encodes a product with pre-mRNA splicing factor activity involved in regulation of nuclear mRNA splicing, via spliceosome which is putatively a component of the spliceosome complex. It has been sequenced and its amino acid sequence contains a RNA-binding region RNP-1 (RNA recognition motif) and a paraneoplastic encephalomyelitis antigen. It has been mapped by recombination to 1-19.2 and cytologically to 6F3--5. It interacts genetically with snf, vir, mle, otu, sc and 21 other listed genes. There are 155 recorded alleles: 81 in vitro constructs (none available from the public stock centers), 72 classical mutants (7 available from the public stock centers) and 2 wild-type. Loss-of-function mutations have been isolated which affect the gonad, the ovary and the egg and are female recessive lethal, reduced female viable, female (with Sxlfhv1) lethal and recessive female sterile. Sxl is discussed in 519 references (excluding sequence accessions), dated between 1960 and 2004. These include at least 99 studies of mutant phenotypes, 6 studies of wild-type function, 2 studies of natural polymorphisms and 16 molecular studies. Among findings on Sxl mutants, tumorous cells produced by Sxl mutants are capable of female-specific transcription and RNA processing indicating the ovarian cells retain some female identity. Among findings on Sxl function, recombination and disjunction in female germ cells depend on the germline activity of Sxl.

FlyBase Gene Summary FBgn0003449 snf sans fille Drosophila melanogaster CG4528 CG4528 fs(1)1621 liz fs(1)A1621 snRNP B'' fs(1)A16121 snf1621 U2 snRNP B'' protein SNF/D25 splicing necessary factor SNF Snf D25 simply not fertile snf 20 Aug 04 X 5049861..5051114 AE003433 snf-RA snf-PA (216 aa) RNA binding RNA binding inferred from sequence similarity mRNA binding mRNA binding non-traceable author statement U1 snRNA binding non-traceable author statement pre-mRNA splicing factor activity inferred from sequence similarity with HUGO:SNRPA; OMIM:182285 pre-mRNA splicing factor activity traceable author statement pre-mRNA splicing factor activity U1 snRNA binding RNA splicing female germ-line sex determination nuclear mRNA splicing, via spliceosome oogenesis (sensu Insecta) primary sex determination, soma nucleus small nuclear ribonucleoprotein complex snRNP U1 snRNP U11 snRNP U2 spliceosome complex IPR000504 == RNA-binding region RNP-1 (RNA recognition motif) SCOP:54928 == RNA-binding domain, RBD; snf|FBgn0003449|pp-CT14684|FBan0004528 DEDB:528 FlyGRID:FBgn0003449 IFly:../dbzhnsky/sansfil1.htm KWgx:FBgn0003449 NCBI_GEO:FBgn0003449 FBrf0125416 Schutt and Nothiger 2000 Development 127(4): 667--677 Review FBrf0102142 Gellon and McGinnis 1998 BioEssays 20(2): 116--125 Review FBrf0100730 Mizzen and Allis 1998 Cell. Molec. Life Sci. 54(1): 6--20 Review

The D. melanogaster gene sans fille, abbreviated as snf, is reported here. It encodes a product with U1 snRNA binding involved in nuclear mRNA splicing, via spliceosome which is localized to the nucleus. It has been sequenced and its amino acid sequence contains a RNA-binding region RNP-1 (RNA recognition motif). It has been mapped by recombination to 1-11.7 and cytologically to 4F4. It interacts genetically with Sxl, ovo, Aats-asp, Aats-trp, da and 3 other listed genes. There are 15 recorded alleles: 6 in vitro constructs (2 available from the public stock centers), 8 classical mutants (2 available from the public stock centers) and 1 wild-type. Hypomorphic mutations have been isolated which affect the ovary and are recessive female sterile, female sterile germ-line-dependent, dominant maternal effect lethal and viable. snf is discussed in 121 references (excluding sequence accessions), dated between 1975 and 2004. These include at least 23 studies of mutant phenotypes, 2 studies of wild-type function and 6 molecular studies. Among findings on snf mutants, tumorous cells produced by snf mutants are capable of female-specific transcription and RNA processing indicating the ovarian cells retain some female identity.

FlyBase Gene Summary FBgn0016917 Stat92E Signal-transducer and activator of transcription protein at 92E Drosophila melanogaster CG4257 Stat1&agr;-like marelle D-Stat mrl: marelle Stat stat d-STAT D-STAT l(3)06346 dSTAT stat92E D-stat STAT Dstat92E Dstat 92E Dstat DSTAT mrl stat92E DRODSRC DSRC SD-stat STAT 92E dSTAT92E/marelle STAT92E Stat92E/marelle D-stat/stat92E mrL DmSTAT l(3)j6C8 mrl Signal-transducer and activator of transcription protein 20 Aug 04 3R complement(16361422..16378051) AE003731 Stat92E-RE Stat92E-PE (754 aa) Stat92E-RF Stat92E-PF (761 aa) Stat92E-RC Stat92E-PC (754 aa) Stat92E-RB Stat92E-PB (628 aa) DNA binding DNA binding traceable author statement DNA binding inferred from sequence similarity with HUGO:STAT5A; OMIM:601511 DNA binding inferred from sequence similarity with HUGO:STAT6; OMIM:601512 RNA polymerase II transcription factor activity non-traceable author statement transcription factor activity traceable author statement RNA polymerase II transcription factor activity transcription factor activity RNA polymerase II transcription factor activity inferred from sequence similarity with UniProt:P51692 JAK-STAT cascade anti-apoptosis blastoderm segmentation border cell migration (sensu Insecta) cellular defense response defense response eye morphogenesis (sensu Drosophila) germ-line stem cell renewal hemocyte proliferation (sensu Arthropoda) hemopoiesis hindgut morphogenesis humoral immune response lamellocyte differentiation mesoderm development neurogenesis oogenesis (sensu Insecta) primary sex determination regulation of transcription regulation of transcription from Pol II promoter sex determination signal transduction somatic stem cell renewal stem cell maintenance stem cell renewal tracheal cell fate determination (sensu Insecta) tracheal system development (sensu Insecta) wing morphogenesis cytoplasm nucleus embryo mesoderm embryonic/larval hindgut embryonic/larval foregut gonad IPR000980 == Src homology 2 (SH2) domain IPR001217 == STAT protein SCOP:47655 == STAT; Stat92E|FBgn0016917|pp-CT13948|FBan0004257 SCOP:49417 == p53-like transcription factors; Stat92E|FBgn0016917|pp-CT13948|FBan0004257 SCOP:55550 == SH2 domain; Stat92E|FBgn0016917|pp-CT13948|FBan0004257 DEDB:9953 FlyGRID:FBgn0016917 Hybrigenics:522066 IFly:../gene/marelle.htm KWgx:FBgn0016917 NCBI_GEO:FBgn0016917 FBrf0155682 Silver and Montell 2003 Dev. Cell 4(2): 148--149 Review FBrf0151864 Castelli-Gair Hombria and Brown 2002 Curr. Biol. 12(16): R569--R575 Review FBrf0155676 Hou et al. 2002 Dev. Cell 3(6): 765--778 Review FBrf0155987 Lin 2002 Nature Rev. Genet. 3(12): 931--940 Review

The D. melanogaster gene Signal-transducer and activator of transcription protein at 92E, abbreviated as Stat92E, is reported here. It has also been known in FlyBase as Stat, l(3)06346 and mare. It encodes a product with DNA binding involved in JAK-STAT cascade which is a component of the nucleus; it is expressed in the embryo (embryonic/larval foregut, embryonic/larval hindgut, gonad and mesoderm). It has been sequenced. It has been mapped by recombination to 3-68.9 and cytologically to 92F1. It interacts genetically with hop, os, dome, tor, Su(var)2-10 and 5 other listed genes. There are 32 recorded alleles: 16 in vitro constructs (none available from the public stock centers), 15 classical mutants (1 available from the public stock centers) and 1 wild-type. Amorphic mutations have been isolated which affect the embryonic abdominal segment 4 to 5, the embryonic head, the telson and 39 other listed tissues and are embryonic rescuable maternal effect recessive lethal, somatic clone wild-type, pupal conditional ts (with Stat92EF) lethal, conditional ts (with Stat92EF) female sterile and (with Stat92EF) male sterile. Stat92E is discussed in 162 references (excluding sequence accessions), dated between 1994 and 2004. These include at least 15 studies of mutant phenotypes, 5 studies of wild-type function and 5 molecular studies. Among findings on Stat92E function, Stat92E is involved in proper differentiation and morphogenesis of multiple tissues.

FlyBase Gene Summary FBgn0004650 fs(1)N female sterile (1) Nasrat Drosophila melanogaster CG11411 CG11411 CG11411 CG11411 fs(1)K1540 371 fs(1)M6 fs(1)Nasrat fs(1)Nas fs(1)A371 Nasrat 8D8.1 EG:8D8.1 fs(1)<up>nas</up> 20 Aug 04 X 1079962..1086891 AE003420 fs(1)N-RA fs(1)N-PA (2118 aa) determination of anterior/posterior axis, embryo insect chorion formation oogenesis (sensu Insecta) DEDB:156 FlyGRID:FBgn0004650 Hybrigenics:522656 NCBI_GEO:FBgn0004650 FBrf0111327 Baek and Lee 1999 J. Biomed. Sci. 6(5): 314--319 Review

The D. melanogaster gene female sterile (1) Nasrat, abbreviated as fs(1)N, is reported here. It has also been known in FlyBase as EG:8D8.1. It encodes a product involved in determination of anterior/posterior axis, embryo. It has been sequenced and its amino acid sequence is also available. It has been mapped by recombination to 1-0.0 and cytologically to 1F3. It interacts genetically with tsl. There are 26 recorded alleles: 4 in vitro constructs (none available from the public stock centers), 21 classical mutants (3 available from the public stock centers) and 1 wild-type. Loss-of-function mutations have been isolated which affect the maternal effect cephalopharyngeal skeleton, the anterior maternal effect head, the maternal effect telson and 3 other listed tissues and are embryonic maternal effect lethal, embryonic maternal effect terminal (with fs(1)N12) lethal and embryonic terminal (with fs(1)N&Dgr;6) lethal. fs(1)N is discussed in 60 references (excluding sequence accessions), dated between 1957 and 2003. These include at least 4 studies of mutant phenotypes, one study of wild-type function and 2 molecular studies. Among findings on fs(1)N mutants, mutations of fs(1)N produce eggs with vitelline membrane defects and some embryos with defective development.

FlyBase Gene Summary FBgn0001291 Jra Jun-related antigen Drosophila melanogaster CG2275 CG2275 l(2)IA109 dJRA dJra Djun d-JRA jun dAP-1 dm-Jun Jun D-jun D-Jun DJun dJUN Jun oncogene l(2R)IA109 V: transcript group V DJUN dJun c-Jun d-Jun cJun Complementation group V jra AP1 d-jun AP-1 l(2)46Ef lethal(2)IA109 lethal(2)1A109 V 20 Aug 04 2R 5157113..5159238 AE003831 Jra-RA Jra-PA (289 aa) Jra-RB Jra-PB (289 aa) transcription factor binding transcription factor binding non-traceable author statement transcription factor binding traceable author statement specific RNA polymerase II transcription factor activity non-traceable author statement protein heterodimerization activity inferred from sequence similarity RNA polymerase II transcription factor activity specific RNA polymerase II transcription factor activity protein heterodimerization activity RNA polymerase II transcription factor activity inferred from sequence similarity with UniProt:P27921 JNK cascade MAPKKK cascade R3/R4 cell fate commitment R7 cell fate commitment dorsal appendage formation dorsal closure establishment of planar polarity micropyle formation regulation of transcription from Pol II promoter cytoplasm nucleus IPR001630 == cAMP response element binding (CREB) protein IPR001871 == bZIP (Basic-leucine zipper) transcription factor family IPR002112 == Jun transcription factor SCOP:47454 == Binding domain of Skn-1; Jra|FBgn0001291|pp-CT7577|FBan0002275 DEDB:12928 FlyGRID:FBgn0001291 IFly:../gene/djun.htm KWgx:FBgn0001291 NCBI_GEO:FBgn0001291 FBrf0156094 Mlodzik 2002 Trends Genet. 18(11): 564--571 Review FBrf0149002 Van Aelst and Symons 2002 Genes Dev. 16(9): 1032--1054 Review FBrf0139822 Jacinto et al. 2001 Nature Cell Biol. 3(5): E117--E123 Review

The D. melanogaster gene Jun-related antigen, abbreviated as Jra, is reported here. It has also been known in FlyBase as l(2)46Ck, l(2)46Ef and l(2)IA109. It encodes a product with transcription factor binding involved in JNK cascade which is localized to the nucleus; it is expressed in the embryo (amnioserosa, cephalic furrow and dorsal ectoderm) and larva (cone cell, morphogenetic furrow, mystery cell, ommatidial cluster and photoreceptor cell). It has been sequenced and its amino acid sequence contains a cAMP response element binding (CREB) domain, a bZIP (Basic-leucine zipper) transcription factor family and a jun transcription factor. It has been mapped by recombination to 2-60 and cytologically to 46E4--5. It interacts genetically with sev, pnt, rl, Rac1, bsk and 24 other listed genes. There are 23 recorded alleles: 17 in vitro constructs (2 available from the public stock centers), 5 classical mutants (1 available from the public stock centers) and 1 wild-type. Amorphic mutations have been isolated which affect the dorsal embryonic epidermis, the head, the somatic clone ommatidium and 2 other listed tissues and are embryonic recessive lethal, somatic clone tissue polarity and (with Df(2R)X1) lethal. Jra is discussed in 160 references (excluding sequence accessions), dated between 1984 and 2004. These include at least 29 studies of mutant phenotypes, 5 studies of wild-type function and 8 molecular studies. Among findings on Jra function, Jra function is not required for the specification of cell fate in the eye.

FlyBase Gene Summary FBgn0005638 slbo slow border cells Drosophila melanogaster CG4354 C/EBP DmC/EBP DC/EBP slobo fs(2)7 fs(2)8 fs(2)ry7 fs(2)ry8 CCAAT/enhancer binding protein 20 Aug 04 2R complement(19375090..19377874) AE003463 slbo-RA slbo-PA (449 aa) DNA binding DNA binding non-traceable author statement transcription regulator activity non-traceable author statement protein heterodimerization activity inferred from sequence similarity transcription regulator activity protein heterodimerization activity border cell migration (sensu Insecta) cell fate specification regulation of transcription, DNA-dependent nucleus oogenesis, adult ovary centripetally migrating follicle cell border follicle cell IPR001871 == bZIP (Basic-leucine zipper) transcription factor family DEDB:1646 FlyGRID:FBgn0005638 IFly:../newgene/slowbo1.htm KWgx:FBgn0005638 NCBI_GEO:FBgn0005638 FBrf0128450 Dobens and Raftery 2000 Dev. Dynamics 218(1): 80--93 Review FBrf0108951 Montell 1999 Development 126(14): 3035--3046 Review FBrf0103248 Deng and Bownes 1998 Int. J. Dev. Biol. 42(4): 541--552 Review

The D. melanogaster gene slow border cells, abbreviated as slbo, is reported here. It has also been known in FlyBase as fs(2)7. It encodes a product with DNA binding involved in border cell migration (sensu Insecta) which is localized to the nucleus; it is expressed in the embryo (embryonic/larval anterior spiracle, embryonic/larval foregut, embryonic/larval hindgut, embryonic/larval midgut and 3 other listed tissues) and ovary (border follicle cell, centripetally migrating follicle cell and ovary). It has been sequenced and its amino acid sequence contains a bZIP (Basic-leucine zipper) transcription factor family. It has been mapped cytologically to 60C6. It interacts genetically with mbc, btl, Ets97D, Ras85D, &agr;-Adaptin and 9 other listed genes. There are 64 recorded alleles: 50 in vitro constructs (none available from the public stock centers), 13 classical mutants (2 available from the public stock centers) and 1 wild-type. Loss-of-function mutations have been isolated which affect the border follicle cell and are female fertile. slbo is discussed in 78 references (excluding sequence accessions), dated between 1982 and 2004. These include at least 13 studies of mutant phenotypes, one study of wild-type function, one study of natural polymorphisms and 4 molecular studies.

FlyBase Gene Summary FBgn0003460 so sine oculis Drosophila melanogaster CG11121 mda Drl: Droplet somda So ami med: medusa old: optic lobe defective Drl optic lobe defective Droplet absent minded medusa 20 Aug 04 2R 2479933..2495773 AE003841 so-RA so-PA (416 aa) transcription factor activity traceable author statement RNA polymerase II transcription factor activity transcription factor activity RNA polymerase II transcription factor activity inferred from sequence similarity with UniProt:Q62231 Bolwig's organ morphogenesis circadian rhythm eye morphogenesis (sensu Drosophila) eye-antennal disc metamorphosis glia cell migration optic placode formation (sensu Drosophila) regulation of transcription regulation of transcription from Pol II promoter spermatogenesis nucleus embryo optic lobe placode epidermis Bolwig's organ optic lobe larva eye disc IPR001356 == Homeobox domain SCOP:46689 == Homeodomain-like; so|FBgn0003460|pp-CT8839|FBan0011121 BDGPisx:so DEDB:13328 FlyGRID:FBgn0003460 IFly:../neural/sineocul.htm NCBI_GEO:FBgn0003460 FBrf0145194 Foster and Helfrich-Foerster 2001 Phil. Trans. r. Soc. B. 356(1415): 1779--1789 Review FBrf0125060 Relaix and Buckingham 1999 Genes Dev. 13(24): 3171--3178 Review FBrf0111566 Treisman 1999 BioEssays 21(10): 843--850 Review

The D. melanogaster gene sine oculis, abbreviated as so, is reported here. It encodes a product with transcription factor activity involved in regulation of transcription which is localized to the nucleus; it is expressed in the adult (ocellus, optic lobe and photoreceptor cell R1 to 7), embryo (Bolwig's organ, epidermis, optic lobe and optic lobe placode) and larva (eye disc, eye-antennal disc and photoreceptor cell R1 to 7). It has been sequenced and its amino acid sequence contains a homeobox domain. It has been mapped by recombination to 2-57.1 and cytologically to 43B3--C1. It interacts genetically with eya, ey, tsh, dpp and gish. There are 36 recorded alleles: 3 in vitro constructs (none available from the public stock centers), 32 classical mutants (3 available from the public stock centers) and 1 wild-type. Amorphic mutations have been isolated which affect the visual primordium, the Bolwig's organ, the somatic clone eye disc and 4 other listed tissues and are embryonic recessive lethal, (with so9) viable and male (with so9) fertile. so is discussed in 197 references (excluding sequence accessions), dated between 1941 and 2004. These include at least 15 studies of mutant phenotypes, 4 studies of wild-type function and 6 molecular studies. Among findings on so mutants, mutants of so display a degraded ERG response.

FlyBase Gene Summary FBgn0000117 arm armadillo Drosophila melanogaster CG11579 CG11579 CG11579 CG11579 CG11579 CG11579 CG11579 l(1)arm &bgr;-catenin l(1)G0234 l(1)G0192 Armadillo beta-catenin Arm &bgr;-Catenin EG:86E4.6 l(1)G0410 &Bgr;-catenin b-catenin ARM t12687 ALR Dm catenin Beta-catenin l(1)2Bv 20 Aug 04 X complement(1648173..1657412) AE003422 arm-RA arm-PA (843 aa) arm-RB arm-PB (843 aa) arm-RC arm-PC (721 aa) arm-RE arm-PE (843 aa) arm-RD arm-PD (843 aa) cytoskeletal protein binding inferred from sequence similarity cytoskeletal protein binding alpha-catenin binding non-traceable author statement structural constituent of cytoskeleton inferred from electronic annotation receptor binding inferred from electronic annotation structural constituent of cytoskeleton receptor binding alpha-catenin binding Wnt receptor signaling pathway cell adhesion cell-cell adhesion cytoskeletal anchoring dorsal closure ectoderm development establishment and/or maintenance of cell polarity frizzled signaling pathway germ-line stem cell renewal heart development neuroblast cell fate determination oocyte positioning oogenesis (sensu Insecta) ovarian follicle cell development (sensu Insecta) positive regulation of JNK cascade protein localization regulation of cell shape segment polarity determination somatic stem cell maintenance zonula adherens assembly adherens junction apicolateral plasma membrane catenin complex cytoplasm membrane spot adherens junction zonula adherens SCOP:48371 == ARM repeat; arm|FBgn0000117|pp-CT12773|FBan0011579 SCOP:48371 == ARM repeat; arm|FBgn0000117|pp-CT36518|FBan0011579 SCOP:48371 == ARM repeat; arm|FBgn0000117|pp-CT36522|FBan0011579 DEDB:229 FlyGRID:FBgn0000117 IFly:../segment/armadilo.htm NCBI_GEO:FBgn0000117 FBrf0159315 Cereijido et al. 2003 Prog. Biophys. Molec. Biol. 81(2): 81--115 Review FBrf0155680 Muller 2003 Dev. Cell 4(1): 1--3 Review FBrf0151433 Bienz 2002 Nature Rev. Molec. Cell. Biol. 3(5): 328--338 Review FBrf0151249 Cripps and Olson 2002 Dev. Biol. 246(1): 14--28 Review FBrf0156092 Galis et al. 2002 Trends Genet. 18(10): 504--509 Review FBrf0155667 Jin and Harper 2002 Dev. Cell 2(6): 685--687 Review FBrf0155493 Knust and Bossinger 2002 Science 298(5600): 1955--1959 Review FBrf0155987 Lin 2002 Nature Rev. Genet. 3(12): 931--940 Review FBrf0151776 Pandur et al. 2002 BioEssays 24(10): 881--884 Review FBrf0151324 Seto et al. 2002 Genes Dev. 16(11): 1314--1336 Review FBrf0155643 Wedlich 2002 Curr. Opin. Cell Biol. 14(5): 563--568 Review

The D. melanogaster gene armadillo, abbreviated as arm, is reported here. It has also been known in FlyBase as l(1)G0192, l(1)G0234 and l(1)G0410. It encodes a product with alpha-catenin binding involved in segment polarity determination which is localized to the cell-cell adherens junction, the intercellular junction and the plasma membrane; it is expressed in the adult (head), embryo (Malpighian tubule, antennal segment, axon, embryonic central nervous system and 22 other listed tissues), larva (embryonic/larval digestive system, embryonic/larval salivary gland, eye-antennal disc, imaginal disc and 5 other listed tissues) and ovary (follicle cell, nurse cell and oocyte). It has been sequenced and its amino acid sequence is also available. It has been mapped by recombination to 1-1.2 and cytologically to 2B14. It interacts genetically with pan, shg, wg, nkd, sgg and 49 other listed genes. There are 146 recorded alleles: 84 in vitro constructs (2 available from the public stock centers), 61 classical mutants (4 available from the public stock centers) and 1 wild-type. Amorphic mutations have been isolated which affect the embryonic somatic clone cell autonomous segment, the embryonic head, the dorsal embryonic epidermis and 20 other listed tissues and are embryonic segment polarity recessive lethal. arm is discussed in 815 references (excluding sequence accessions), dated between 1982 and 2004. These include at least 69 studies of mutant phenotypes, 10 studies of wild-type function and 26 molecular studies. Among findings on arm mutants, arm mutants display mirror image duplication of denticle belts. Among findings on arm function, arm does not play a general role in inhibiting cell migration or process extension.

FlyBase Gene Summary FBgn0000308 chic chickadee Drosophila melanogaster CG9553 CG9553 sand D88 l(2)27/7 profilin Profilin chi Chic Chi stranded 20 Aug 04 2L complement(5965115..5973240) AE003612 chic-RD chic-PD (126 aa) chic-RB chic-PB (126 aa) chic-RC chic-PC (126 aa) chic-RA chic-PA (126 aa) actin binding actin binding inferred from sequence similarity actin binding non-traceable author statement phosphatidylinositol-4,5-bisphosphate binding non-traceable author statement structural constituent of cytoskeleton inferred from electronic annotation structural constituent of cytoskeleton phosphatidylinositol-4,5-bisphosphate binding actin filament organization actin filament polymerization actin polymerization and/or depolymerization cytokinesis, contractile ring formation dorsal closure nurse cell to ocyte transport (sensu Insecta) pole plasm oskar mRNA localization spermatogenesis oogenesis, adult ovary SCOP:55770 == Profilin (actin-binding protein); chic|FBgn0000308|pp-CT27020|FBan0009553 SCOP:55770 == Profilin (actin-binding protein); chic|FBgn0000308|pp-CT36595|FBan0009553 DEDB:6587 FlyGRID:FBgn0000308 IFly:../cytoskel/chickd1.htm KWgx:FBgn0000308 NCBI_GEO:FBgn0000308 FBrf0151730 Hudson and Cooley 2002 A. Rev. Genet. 36: 455--488 Review FBrf0151872 Martin and Wood 2002 Curr. Opin. Cell Biol. 14(5): 569--574 Review FBrf0151773 Mazumdar and Mazumdar 2002 BioEssays 24(11): 1012--1022 Review FBrf0149002 Van Aelst and Symons 2002 Genes Dev. 16(9): 1032--1054 Review

The D. melanogaster gene chickadee, abbreviated as chic, is reported here. It has also been known in FlyBase as chi and sand. It encodes a product with actin binding involved in spermatogenesis which is expressed in the embryo (ventral nerve cord) and ovary (border follicle cell, follicle cell, nurse cell and ovary). It has been sequenced and its amino acid sequence is also available. It has been mapped cytologically to 26A5--B2. It interacts genetically with capu, Abl, cib, Ras85D, Cdc42 and 3 other listed genes. There are 45 recorded alleles: 2 in vitro constructs (none available from the public stock centers), 42 classical mutants (4 available from the public stock centers) and 1 wild-type. Amorphic mutations have been isolated which affect the nurse cell, the border follicle cell, the wing and 7 other listed tissues and are recessive lethal, recessive semi-lethal and recessive male sterile. chic is discussed in 152 references (excluding sequence accessions), dated between 1988 and 2004. These include at least 12 studies of mutant phenotypes, 3 studies of wild-type function and 10 molecular studies. Among findings on chic mutants, mutations at the chic locus cause defects in midoogenesis. Among findings on chic function, chic regulates actin filament formation throughout the cell cortex in the follicular epithelium.

FlyBase Gene Summary FBgn0001233 Hsp83 Heat shock protein 83 Drosophila melanogaster CG1242 CG1242 CG1242 hsp83 83K HSP hsp82 83 Hsp82 E(sev)3A: Enhancer of sevenless 3A hsp84 l(3)j5C2 E(sina)2 HSP83 Hsp90 clone 2.53 HSP90 hsp90 DMHSP82 HSP82 ms(3)08445 ORF1 en(lz)3C/4C anon-WO0068693 Su(Raf)3A anon-EST:Liang-2.53 stc E(sev)3A scratch Enhancer of seven in absentia 2 Enhancer of sevenless 3A 20 Aug 04 3L 3173656..3177690 AE003477 Hsp83-RA Hsp83-PA (717 aa) ATPase activity, coupled inferred from sequence similarity with EMBL:J04988 ATPase activity, coupled R7 cell fate commitment actin filament organization centrosome cycle defense response determination of anterior/posterior axis, embryo protein complex assembly protein folding regulation of cell shape regulation of circadian sleep/wake cycle, sleep response to heat spermatogenesis torso signaling pathway centrosome cytoplasm IPR003594 == Histidine kinase-like ATPase SCOP:48264 == Cytochrome P450; Hsp83|FBgn0001233|pp-CT2354|FBan0001242 SCOP:55874 == ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; Hsp83|FBgn0001233|pp-CT2354|FBan0001242 DEDB:2150 FlyGRID:FBgn0001233 Hybrigenics:522751 NCBI_GEO:FBgn0001233 FBrf0156003 Rutherford and Henikoff 2003 Nature Genetics 33(1): 6--8 Review FBrf0157214 Tatar et al. 2003 Science 299(5611): 1346--1351 Review FBrf0156039 Ohta 2002 Proc. Natl. Acad. Sci. USA 99(25): 16134--16137 Review FBrf0156097 Tekotte and Davis 2002 Trends Genet. 18(12): 636--642 Review

The D. melanogaster gene Heat shock protein 83, abbreviated as Hsp83, is reported here. It has also been known in FlyBase as Su(Raf)3A, l(3)j5C2 and ms(3)08445. It encodes a product with ATPase activity, coupled involved in centrosome cycle which is a component of the cytoplasm. It has been sequenced and its amino acid sequence contains a histidine kinase-like ATPase. It has been mapped by recombination to 3-5 and cytologically to 63B11. It interacts genetically with sev, sina, phl, lz and tor. There are 65 recorded alleles: 49 in vitro constructs (1 available from the public stock centers), 15 classical mutants (4 available from the public stock centers) and 1 wild-type. Hypomorphic mutations have been isolated which affect the spermatocyte, the spermatid, the Nebenkern and the spermatozoon and are recessive lethal. Hsp83 is discussed in 226 references (excluding sequence accessions), dated between 1970 and 2004. These include at least 21 studies of mutant phenotypes, 7 studies of wild-type function, 4 studies of natural polymorphisms and 11 molecular studies. Among findings on Hsp83 function, Hsp83 may have a role in ensuring proper centrosome function.

FlyBase Gene Summary FBgn0000463 Dl Delta Drosophila melanogaster CG3619 CG3619 C1 D 0495/20 0926/11 1053/14 1119/09 1304/03 1423/11 1440/11 1485/04 dmDelta delta D1 delta Overflow CT12133 l(3)05151 l(3)92Ab l(3)j8C3 Complementation group 1 20 Aug 04 3R complement(15128470..15151952) AE003725 Dl-RB Dl-PB (833 aa) Dl-RA Dl-PA (833 aa) receptor binding non-traceable author statement Notch binding non-traceable author statement Notch binding inferred from direct assay Notch binding traceable author statement signal transducer activity traceable author statement receptor binding Notch binding signal transducer activity Notch signaling pathway R3/R4 cell fate commitment R8 differentiation antennal morphogenesis asymmetric cytokinesis cell adhesion cell fate specification cell proliferation cell-cell adhesion central nervous system development cone cell fate commitment (sensu Drosophila) dorsal/ventral lineage restriction, imaginal disc ectoderm development establishment of ommatidial polarity (sensu Drosophila) establishment of planar polarity eye morphogenesis (sensu Drosophila) lateral inhibition leg morphogenesis (sensu Holometabola) mesoderm development negative regulation of fusion cell fate specification negative regulation of terminal cell fate specification neurogenesis ommatidial rotation oocyte anterior/posterior axis determination oogenesis (sensu Insecta) ovarian follicle cell development (sensu Insecta) peripheral nervous system development regulation of R8 spacing restriction of R8 fate retinal programmed cell death (sensu Drosophila) tracheal system development (sensu Insecta) ventral cord development wing vein specification integral to membrane plasma membrane embryo neuroblast posterior embryonic/larval midgut hindgut primordium neurectoderm ectoderm ventral midline embryonic peripheral nervous system embryonic stomatogastric nervous system procephalic neurogenic region embryonic/larval tracheal system larva photoreceptor cell R3 IPR001774 == Delta serrate ligand IPR001881 == Calcium-binding EGF-like domain SCOP:57196 == EGF/Laminin; dl|FBgn0000462|pp-CT12133|FBan0003619 BDGPisx:Dl DEDB:9797 FlyGRID:FBgn0000463 Hybrigenics:521443 IFly:../neural/delta.htm KWgx:FBgn0000463 NCBI_GEO:FBgn0000463 FBrf0158840 Skeath and Thor 2003 Curr. Opin. Neurobiol. 13(1): 8--15 Review FBrf0158727 de Celis 2003 BioEssays 25(5): 443--451 Review FBrf0144824 Frankfort and Mardon 2002 Development 129(6): 1295--1306 Review FBrf0156092 Galis et al. 2002 Trends Genet. 18(10): 504--509 Review FBrf0147184 Gorski and Marra 2002 Physiol. Genomics 9(2): 59--69 Review FBrf0155573 Haltiwanger and Stanley 2002 Biochim. biophys. Acta 1573(3): 328--335 Review FBrf0151530 Martinez Arias 2002 Trends Genet. 18(4): 168--170 Review FBrf0156094 Mlodzik 2002 Trends Genet. 18(11): 564--571 Review FBrf0151324 Seto et al. 2002 Genes Dev. 16(11): 1314--1336 Review FBrf0151490 Stewart 2002 Semin. Cell Dev. Biol. 13(2): 91--97 Review FBrf0149002 Van Aelst and Symons 2002 Genes Dev. 16(9): 1032--1054 Review

The D. melanogaster gene Delta, abbreviated as Dl, is reported here. It encodes a product with Notch binding involved in mesoderm development which is a component of the integral to membrane; it is expressed in the embryo (amnioproctodeal invagination, antenno-maxillary complex, anterior embryonic/larval midgut, anterior midgut primordium and 32 other listed tissues), larva (antennal disc, cone cell, eye disc, glial cell and 14 other listed tissues), ovary (centripetally migrating follicle cell, follicle cell, germarium region 1 to 3, nurse cell and oocyte) and prepupa and pupa (macrochaetae, microchaetae, proneural cluster, sensillum campaniformium and 4 other listed tissues). It has been sequenced and its amino acid sequence contains a delta serrate ligand and a calcium-binding EGF-like domain. It has been mapped by recombination to 3-66.2 and cytologically to 92A1--2. It interacts genetically with H, Su(H), Ser, Egfr, ed and 74 other listed genes. There are 350 recorded alleles: 40 in vitro constructs (3 available from the public stock centers), 309 classical mutants (17 available from the public stock centers) and 1 wild-type. Amorphic mutations have been isolated which affect the embryonic epidermis, the wing, the eye and 10 other listed tissues and are embryonic neurogenic recessive lethal, somatic clone cell lethal, visible and (with DlRF) visible. Dl is discussed in 837 references (excluding sequence accessions), dated between 1923 and 2004. These include at least 126 studies of mutant phenotypes, 9 studies of wild-type function, 3 studies of natural polymorphisms and 22 molecular studies. Among findings on Dl mutants, mutation in Dl affects sensory organ precursor formation. Among findings on Dl function, Dl has a role in leg and antennal segmentation.

FlyBase Gene Summary FBgn0000490 dpp decapentaplegic Drosophila melanogaster CG9885 CG9885 ho: heldout M(2)LS1 shv l(2)22Fa Dpp DPP TGF-&bgr; l(2)10638 l(2)k17036 TGF-b shortvein Dm-DPP TGF-beta TGF&bgr; DPP-C Hin-d: Haplo-insufficient M(2)23AB Tg: Tegula blk: blink blink Haplo-insufficient Tegula heldout ho 20 Aug 04 2L 2421021..2452176 AE003583 dpp-RD dpp-PD (588 aa) dpp-RC dpp-PC (588 aa) dpp-RE dpp-PE (588 aa) dpp-RA dpp-PA (588 aa) dpp-RB dpp-PB (588 aa) signal transducer activity traceable author statement morphogen activity traceable author statement morphogen activity non-traceable author statement transforming growth factor beta receptor binding non-traceable author statement transforming growth factor beta receptor binding inferred from sequence similarity with MGD:Bmp4; MGI:MGI:88180 morphogen activity signal transducer activity transforming growth factor beta receptor binding BMP signaling pathway amnioserosa formation anterior/posterior axis specification anterior/posterior pattern formation, imaginal disc branch cell fate determination (sensu Insecta) cell fate determination cell fate specification cell-cell signaling compound eye morphogenesis (sensu Drosophila) dorsal closure dorsal closure, leading edge cell fate determination dorsal/ventral axis specification dorsal/ventral pattern formation, imaginal disc ectoderm cell fate specification ectoderm development embryonic morphogenesis foregut morphogenesis genital disc development germ-line stem cell division germ-line stem cell renewal heart development hindgut morphogenesis imaginal disc development imaginal disc growth imaginal disc pattern formation larval development (sensu Insecta) leg disc proximal/distal pattern formation negative regulation of cell proliferation negative regulation of salivary gland determination nurse cell apoptosis oogenesis (sensu Insecta) ovarian follicle cell development (sensu Insecta) pigmentation progression of morphogenetic furrow (sensu Drosophila) regulation of cell proliferation regulation of organ size regulation of tracheal tube diameter stem cell maintenance stem cell renewal tracheal branch fusion tracheal cell fate determination (sensu Insecta) tracheal cell migration (sensu Insecta) tracheal system development (sensu Insecta) transforming growth factor beta receptor signaling pathway wing disc anterior/posterior pattern formation wing disc proximal/distal pattern formation wing morphogenesis wing vein morphogenesis wing vein specification zygotic determination of anterior/posterior axis, embryo zygotic determination of dorsal/ventral axis extracellular extracellular space intracellular embryo parasegment 7 <of> visceral mesoderm embryonic/larval pharynx midgut constriction 3 embryonic/larval hindgut cephalic segment thoracic segment visceral mesoderm <of> parasegment 7 larva dorsal mesothoracic disc cephalic segment thoracic segment ventral thoracic disc prepupa ventral thoracic disc dorsal mesothoracic disc pupa wing vein IPR002405 == Inhibin &agr; chain SCOP:57501 == Cystine-knot cytokines; dpp|FBgn0000490|pp-CT9505|FBan0009885 DEDB:5561 FlyGRID:FBgn0000490 Hybrigenics:522739 IFly:../torstoll/decapen1.htm KWgx:FBgn0000490 NCBI_GEO:FBgn0000490 FBrf0159337 Abrams et al. 2003 Trends Cell Biol. 13(5): 247--254 Review FBrf0158727 de Celis 2003 BioEssays 25(5): 443--451 Review FBrf0152334 Burtis 2002 Science 297(5584): 1135--1136 Review FBrf0151319 Calleja et al. 2002 Gene 292(1-2): 1--12 Review FBrf0151249 Cripps and Olson 2002 Dev. Biol. 246(1): 14--28 Review FBrf0145168 Curtiss et al. 2002 Nature Cell Biol. 4(3): E48--E51 Review FBrf0151731 Duncan 2002 A. Rev. Genet. 36: 521--556 Review FBrf0155987 Lin 2002 Nature Rev. Genet. 3(12): 931--940 Review FBrf0151711 Mann and Casares 2002 Nature 418(6899): 737--739 Review FBrf0151872 Martin and Wood 2002 Curr. Opin. Cell Biol. 14(5): 569--574 Review FBrf0155572 Nakato and Kimata 2002 Biochim. biophys. Acta 1573(3): 312--318 Review FBrf0151324 Seto et al. 2002 Genes Dev. 16(11): 1314--1336 Review FBrf0151490 Stewart 2002 Semin. Cell Dev. Biol. 13(2): 91--97 Review FBrf0149002 Van Aelst and Symons 2002 Genes Dev. 16(9): 1032--1054 Review FBrf0155675 Vincent and Dubois 2002 Dev. Cell 3(5): 615--623 Review

The D. melanogaster gene decapentaplegic, abbreviated as dpp, is reported here. It encodes a product with transforming growth factor beta receptor binding involved in hindgut morphogenesis which is a component of the extracellular space; it is expressed in the embryo (cephalic segment, embryonic brain, embryonic/larval foregut, embryonic/larval hindgut and 8 other listed tissues), larva (dorsal mesothoracic disc, eye-antennal disc, female genital disc, imaginal disc anlagen and 5 other listed tissues) and prepupa and pupa (wing vein, eye-antennal disc, leg disc, wing disc and wing vein). It has been sequenced and its amino acid sequence contains an inhibin &agr; chain. It has been mapped by recombination to 2-4.0 and cytologically to 22F1--3. It interacts genetically with tkv, Mad, Med, ptc, tld and 73 other listed genes. There are 256 recorded alleles: 49 in vitro constructs (2 available from the public stock centers), 206 classical mutants (15 available from the public stock centers) and 1 wild-type. Mutations have been isolated which affect the embryonic dorsal epidermis and the amnioserosa and are embryonic dominant lethal. dpp is discussed in 1543 references (excluding sequence accessions), dated between 1937 and 2004. These include at least 106 studies of mutant phenotypes, 79 studies of wild-type function, 3 studies of natural polymorphisms and 108 molecular studies. Among findings on dpp mutants, allelic complementation at dpp is demonstrated to be a transvection effect, structural heterozygosity disrupts complementation. Among findings on dpp function, wing and eye disc peripodial cell survival hinges upon dpp signal reception. (However, there is much more information on function so that may not be representative.)

FlyBase Gene Summary FBgn0013984 InR Insulin-like receptor Drosophila melanogaster CG18402 CG18402 er10 DILR dir DIRH dIRH dInsR IR DIR DIHR DIR&bgr; dIR inr Inr l(3)05545 DInr INR insulin receptor dinr dInr insulin/insulin-like growth factor receptor dInR DInR Dir-a Dir-b Inr-&agr; Inr-&bgr; l(3)93Dj l(3)er10 lethal(3)93Dj insulin receptor homolog 20 Aug 04 3R complement(17389185..17397215) AE003735 InR-RA InR-PA (2144 aa) insulin-like growth factor binding non-traceable author statement insulin receptor activity inferred from direct assay insulin receptor activity inferred from sequence similarity protein-tyrosine kinase activity ; ; EC:2.7.1.112 non-traceable author statement protein-tyrosine kinase activity ; ; EC:2.7.1.112 insulin receptor activity insulin-like growth factor binding insulin receptor activity inferred from sequence similarity with UniProt:P06213 aging autophosphorylation axon guidance cell growth determination of adult life span dorsal closure embryonic development (sensu Insecta) germ-band shortening growth insulin receptor signaling pathway positive regulation of body size positive regulation of cell growth positive regulation of cell proliferation positive regulation of cell size positive regulation of organ size protein amino acid phosphorylation regulation of body size regulation of cell size regulation of organ size response to nutrients vitellogenesis insulin receptor complex integral to plasma membrane intercellular junction plasma membrane IPR000494 == Epidermal growth-factor receptor (EGFR), L domain IPR000719 == Eukaryotic protein kinase IPR001245 == Tyrosine kinase catalytic domain IPR002011 == Receptor tyrosine kinase class II IPR002174 == Furin-like cysteine rich region SCOP:49265 == Fibronectin type III; InR|FBgn0013984|pp-CT19952|FBan0018402 SCOP:52058 == L domain-like; InR|FBgn0013984|pp-CT19952|FBan0018402 SCOP:56112 == Protein kinase-like (PK-like); InR|FBgn0013984|pp-CT19952|FBan0018402 SCOP:57184 == IGF binding domain; InR|FBgn0013984|pp-CT19952|FBan0018402 DEDB:10062 FlyGRID:FBgn0013984 Hybrigenics:522048 NCBI_GEO:FBgn0013984 FBrf0159325 Dickson 2003 Science 300(5618): 440--441 Review FBrf0155558 Helfand and Rogina 2003 BioEssays 25(2): 134--141 Review FBrf0157213 Longo 2003 Science 299(5611): 1342--1346 Review FBrf0156084 Oldham and Hafen 2003 Trends Cell Biol. 13(2): 79--85 Review FBrf0159736 Saucedo 2003 Curr. Opin. Genet. Dev. 12(5): 565--571 Review FBrf0157214 Tatar et al. 2003 Science 299(5611): 1346--1351 Review

The D. melanogaster gene Insulin-like receptor, abbreviated as InR, is reported here. It has also been known in FlyBase as l(3)93Dj. It encodes a product with insulin receptor activity involved in insulin receptor signaling pathway which is a component of the intercellular junction; it is expressed in the embryo (embryonic/larval hindgut, epidermis, neuroblast, posterior midgut primordium and 2 other listed tissues). It has been sequenced and its amino acid sequence contains an epidermal growth-factor receptor (EGFR), L domain, an eukaryotic protein kinase, a tyrosine kinase catalytic domain, a receptor tyrosine kinase class II and a furin-like cysteine rich region. It has been mapped cytologically to 93E4. It interacts genetically with chico, peb, Pten, Ilp2, Pk61C and 3 other listed genes. There are 49 recorded alleles: 14 in vitro constructs (none available from the public stock centers), 34 classical mutants (1 available from the public stock centers) and 1 wild-type. Hypomorphic mutations have been isolated which affect the longitudinal connective, the commissure, the fascicle and 2 other listed tissues and are embryonic recessive lethal, recessive somatic clone visible, dominant long lived, (with InRE19) small body, (with InRE19) developmental rate defective, (with InRE19) long lived, (with InRE19) female sterile, partially (with InRE19) male sterile and (with InR353) lethal. InR is discussed in 121 references (excluding sequence accessions), dated between 1984 and 2004. These include at least 12 studies of mutant phenotypes, 6 studies of wild-type function and 14 molecular studies. Among findings on InR function, InR is required for photoreceptor cell axons to find their way from the retina to the brain during development of the visual system.